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Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents

Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent surv...

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Detalles Bibliográficos
Autores principales: Callaghan, Cameron M., Hasibuzzaman, M. M., Rodman, Samuel N., Goetz, Jessica E., Mapuskar, Kranti A., Petronek, Michael S., Steinbach, Emily J., Miller, Benjamin J., Pulliam, Casey F., Coleman, Mitchell C., Monga, Varun V., Milhem, Mohammed M., Spitz, Douglas R., Allen, Bryan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465163/
https://www.ncbi.nlm.nih.gov/pubmed/32806601
http://dx.doi.org/10.3390/cancers12082258
Descripción
Sumario:Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins—but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.