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Post-Translational Regulation of ARF: Perspective in Cancer

Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and unhindered cell proliferation. Under such conditions, normal cells autonomously induce defense mechanisms, thereby stimulating tumor suppressor activation. ARF, encoded by the CDKN2a locus, is one of the most freq...

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Autores principales: Seo, Jinho, Seong, Daehyeon, Lee, Seung Ri, Oh, Doo-Byoung, Song, Jaewhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465197/
https://www.ncbi.nlm.nih.gov/pubmed/32759846
http://dx.doi.org/10.3390/biom10081143
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author Seo, Jinho
Seong, Daehyeon
Lee, Seung Ri
Oh, Doo-Byoung
Song, Jaewhan
author_facet Seo, Jinho
Seong, Daehyeon
Lee, Seung Ri
Oh, Doo-Byoung
Song, Jaewhan
author_sort Seo, Jinho
collection PubMed
description Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and unhindered cell proliferation. Under such conditions, normal cells autonomously induce defense mechanisms, thereby stimulating tumor suppressor activation. ARF, encoded by the CDKN2a locus, is one of the most frequently mutated or deleted tumor suppressors in human cancer. The safeguard roles of ARF in tumorigenesis are mainly mediated via the MDM2-p53 axis, which plays a prominent role in tumor suppression. Under normal conditions, low p53 expression is stringently regulated by its target gene, MDM2 E3 ligase, which induces p53 degradation in a ubiquitin-proteasome-dependent manner. Oncogenic signals induced by MYC, RAS, and E2Fs trap MDM2 in the inhibited state by inducing ARF expression as a safeguard measure, thereby activating the tumor-suppressive function of p53. In addition to the MDM2-p53 axis, ARF can also interact with diverse proteins and regulate various cellular functions, such as cellular senescence, apoptosis, and anoikis, in a p53-independent manner. As the evidence indicating ARF as a key tumor suppressor has been accumulated, there is growing evidence that ARF is sophisticatedly fine-tuned by the diverse factors through transcriptional and post-translational regulatory mechanisms. In this review, we mainly focused on how cancer cells employ transcriptional and post-translational regulatory mechanisms to manipulate ARF activities to circumvent the tumor-suppressive function of ARF. We further discussed the clinical implications of ARF in human cancer.
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spelling pubmed-74651972020-09-04 Post-Translational Regulation of ARF: Perspective in Cancer Seo, Jinho Seong, Daehyeon Lee, Seung Ri Oh, Doo-Byoung Song, Jaewhan Biomolecules Review Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and unhindered cell proliferation. Under such conditions, normal cells autonomously induce defense mechanisms, thereby stimulating tumor suppressor activation. ARF, encoded by the CDKN2a locus, is one of the most frequently mutated or deleted tumor suppressors in human cancer. The safeguard roles of ARF in tumorigenesis are mainly mediated via the MDM2-p53 axis, which plays a prominent role in tumor suppression. Under normal conditions, low p53 expression is stringently regulated by its target gene, MDM2 E3 ligase, which induces p53 degradation in a ubiquitin-proteasome-dependent manner. Oncogenic signals induced by MYC, RAS, and E2Fs trap MDM2 in the inhibited state by inducing ARF expression as a safeguard measure, thereby activating the tumor-suppressive function of p53. In addition to the MDM2-p53 axis, ARF can also interact with diverse proteins and regulate various cellular functions, such as cellular senescence, apoptosis, and anoikis, in a p53-independent manner. As the evidence indicating ARF as a key tumor suppressor has been accumulated, there is growing evidence that ARF is sophisticatedly fine-tuned by the diverse factors through transcriptional and post-translational regulatory mechanisms. In this review, we mainly focused on how cancer cells employ transcriptional and post-translational regulatory mechanisms to manipulate ARF activities to circumvent the tumor-suppressive function of ARF. We further discussed the clinical implications of ARF in human cancer. MDPI 2020-08-04 /pmc/articles/PMC7465197/ /pubmed/32759846 http://dx.doi.org/10.3390/biom10081143 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Seo, Jinho
Seong, Daehyeon
Lee, Seung Ri
Oh, Doo-Byoung
Song, Jaewhan
Post-Translational Regulation of ARF: Perspective in Cancer
title Post-Translational Regulation of ARF: Perspective in Cancer
title_full Post-Translational Regulation of ARF: Perspective in Cancer
title_fullStr Post-Translational Regulation of ARF: Perspective in Cancer
title_full_unstemmed Post-Translational Regulation of ARF: Perspective in Cancer
title_short Post-Translational Regulation of ARF: Perspective in Cancer
title_sort post-translational regulation of arf: perspective in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465197/
https://www.ncbi.nlm.nih.gov/pubmed/32759846
http://dx.doi.org/10.3390/biom10081143
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