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Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19

Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase the expression of angiotensin-convertin...

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Autores principales: Bruce, Eilidh, Barlow-Pay, Fenella, Short, Roxanna, Vilches-Moraga, Arturo, Price, Angeline, McGovern, Aine, Braude, Philip, Stechman, Michael J., Moug, Susan, McCarthy, Kathryn, Hewitt, Jonathan, Carter, Ben, Myint, Phyo Kyaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465199/
https://www.ncbi.nlm.nih.gov/pubmed/32785086
http://dx.doi.org/10.3390/jcm9082586
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author Bruce, Eilidh
Barlow-Pay, Fenella
Short, Roxanna
Vilches-Moraga, Arturo
Price, Angeline
McGovern, Aine
Braude, Philip
Stechman, Michael J.
Moug, Susan
McCarthy, Kathryn
Hewitt, Jonathan
Carter, Ben
Myint, Phyo Kyaw
author_facet Bruce, Eilidh
Barlow-Pay, Fenella
Short, Roxanna
Vilches-Moraga, Arturo
Price, Angeline
McGovern, Aine
Braude, Philip
Stechman, Michael J.
Moug, Susan
McCarthy, Kathryn
Hewitt, Jonathan
Carter, Ben
Myint, Phyo Kyaw
author_sort Bruce, Eilidh
collection PubMed
description Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase the expression of angiotensin-converting enzyme 2 (ACE2), a binding target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter the host cell, which could lead to poorer outcomes in COVID-19 disease. The aim of this study was to examine the association between routine use of NSAIDs and outcomes in hospitalised patients with COVID-19. This was a multicentre, observational study, with data collected from adult patients with COVID-19 admitted to eight UK hospitals. Of 1222 patients eligible to be included, 54 (4.4%) were routinely prescribed NSAIDs prior to admission. Univariate results suggested a modest protective effect from the use of NSAIDs, but in the multivariable analysis, there was no association between prior NSAID use and time to mortality (adjusted HR (aHR) = 0.89, 95% CI 0.52–1.53, p = 0.67) or length of stay (aHR 0.89, 95% CI 0.59–1.35, p = 0.58). This study found no evidence that routine NSAID use was associated with higher COVID-19 mortality in hospitalised patients; therefore, patients should be advised to continue taking these medications until further evidence emerges. Our findings suggest that NSAID use might confer a modest benefit with regard to survival. However, as this finding was underpowered, further research is required.
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spelling pubmed-74651992020-09-04 Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19 Bruce, Eilidh Barlow-Pay, Fenella Short, Roxanna Vilches-Moraga, Arturo Price, Angeline McGovern, Aine Braude, Philip Stechman, Michael J. Moug, Susan McCarthy, Kathryn Hewitt, Jonathan Carter, Ben Myint, Phyo Kyaw J Clin Med Article Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase the expression of angiotensin-converting enzyme 2 (ACE2), a binding target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter the host cell, which could lead to poorer outcomes in COVID-19 disease. The aim of this study was to examine the association between routine use of NSAIDs and outcomes in hospitalised patients with COVID-19. This was a multicentre, observational study, with data collected from adult patients with COVID-19 admitted to eight UK hospitals. Of 1222 patients eligible to be included, 54 (4.4%) were routinely prescribed NSAIDs prior to admission. Univariate results suggested a modest protective effect from the use of NSAIDs, but in the multivariable analysis, there was no association between prior NSAID use and time to mortality (adjusted HR (aHR) = 0.89, 95% CI 0.52–1.53, p = 0.67) or length of stay (aHR 0.89, 95% CI 0.59–1.35, p = 0.58). This study found no evidence that routine NSAID use was associated with higher COVID-19 mortality in hospitalised patients; therefore, patients should be advised to continue taking these medications until further evidence emerges. Our findings suggest that NSAID use might confer a modest benefit with regard to survival. However, as this finding was underpowered, further research is required. MDPI 2020-08-10 /pmc/articles/PMC7465199/ /pubmed/32785086 http://dx.doi.org/10.3390/jcm9082586 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bruce, Eilidh
Barlow-Pay, Fenella
Short, Roxanna
Vilches-Moraga, Arturo
Price, Angeline
McGovern, Aine
Braude, Philip
Stechman, Michael J.
Moug, Susan
McCarthy, Kathryn
Hewitt, Jonathan
Carter, Ben
Myint, Phyo Kyaw
Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
title Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
title_full Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
title_fullStr Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
title_full_unstemmed Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
title_short Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
title_sort prior routine use of non-steroidal anti-inflammatory drugs (nsaids) and important outcomes in hospitalised patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465199/
https://www.ncbi.nlm.nih.gov/pubmed/32785086
http://dx.doi.org/10.3390/jcm9082586
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