Cargando…

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes...

Descripción completa

Detalles Bibliográficos
Autores principales: Puchałowicz, Kamila, Rać, Monika Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465275/
https://www.ncbi.nlm.nih.gov/pubmed/32796572
http://dx.doi.org/10.3390/cells9081877
_version_ 1783577552509468672
author Puchałowicz, Kamila
Rać, Monika Ewa
author_facet Puchałowicz, Kamila
Rać, Monika Ewa
author_sort Puchałowicz, Kamila
collection PubMed
description CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic β-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy.
format Online
Article
Text
id pubmed-7465275
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74652752020-09-04 The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring Puchałowicz, Kamila Rać, Monika Ewa Cells Review CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic β-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy. MDPI 2020-08-11 /pmc/articles/PMC7465275/ /pubmed/32796572 http://dx.doi.org/10.3390/cells9081877 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Puchałowicz, Kamila
Rać, Monika Ewa
The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
title The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
title_full The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
title_fullStr The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
title_full_unstemmed The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
title_short The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
title_sort multifunctionality of cd36 in diabetes mellitus and its complications—update in pathogenesis, treatment and monitoring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465275/
https://www.ncbi.nlm.nih.gov/pubmed/32796572
http://dx.doi.org/10.3390/cells9081877
work_keys_str_mv AT puchałowiczkamila themultifunctionalityofcd36indiabetesmellitusanditscomplicationsupdateinpathogenesistreatmentandmonitoring
AT racmonikaewa themultifunctionalityofcd36indiabetesmellitusanditscomplicationsupdateinpathogenesistreatmentandmonitoring
AT puchałowiczkamila multifunctionalityofcd36indiabetesmellitusanditscomplicationsupdateinpathogenesistreatmentandmonitoring
AT racmonikaewa multifunctionalityofcd36indiabetesmellitusanditscomplicationsupdateinpathogenesistreatmentandmonitoring