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The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review

(1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Method...

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Autores principales: Fontaine, Candice, Jacq, Gwenaelle, Perier, François, Holleville, Mathilde, Legriel, Stephane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465284/
https://www.ncbi.nlm.nih.gov/pubmed/32764270
http://dx.doi.org/10.3390/jcm9082521
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author Fontaine, Candice
Jacq, Gwenaelle
Perier, François
Holleville, Mathilde
Legriel, Stephane
author_facet Fontaine, Candice
Jacq, Gwenaelle
Perier, François
Holleville, Mathilde
Legriel, Stephane
author_sort Fontaine, Candice
collection PubMed
description (1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Methods: Electronic searches were conducted in May 2020 using Medline via PubMed, Embase, and Google Scholar (#CRD42019139092). Experimental studies of animals or randomized, observational, controlled trials of patients with SE in indexed journals were included. There were no language or date restrictions for the published literature included in this review. Information was extracted on study design, sample size, SBI characteristics, and primary and secondary outcomes, including the timing of evaluation; (3) Results: Among the 2209 articles responding to our inclusion criteria, 56 were included in this systematic review. There are numerous experimental data reporting the deleterious effects associated with each of the SBI in animals exposed to SE. In humans, only the effect of target temperature management in hypothermia (32–34 °C) has been explored. (4) Conclusions: There is little experimental evidence that favors the control of secondary brain insult after SE. Further studies are required to assess the neuroprotective interest of secondary brain insult control after SE in humans.
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spelling pubmed-74652842020-09-04 The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review Fontaine, Candice Jacq, Gwenaelle Perier, François Holleville, Mathilde Legriel, Stephane J Clin Med Review (1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Methods: Electronic searches were conducted in May 2020 using Medline via PubMed, Embase, and Google Scholar (#CRD42019139092). Experimental studies of animals or randomized, observational, controlled trials of patients with SE in indexed journals were included. There were no language or date restrictions for the published literature included in this review. Information was extracted on study design, sample size, SBI characteristics, and primary and secondary outcomes, including the timing of evaluation; (3) Results: Among the 2209 articles responding to our inclusion criteria, 56 were included in this systematic review. There are numerous experimental data reporting the deleterious effects associated with each of the SBI in animals exposed to SE. In humans, only the effect of target temperature management in hypothermia (32–34 °C) has been explored. (4) Conclusions: There is little experimental evidence that favors the control of secondary brain insult after SE. Further studies are required to assess the neuroprotective interest of secondary brain insult control after SE in humans. MDPI 2020-08-05 /pmc/articles/PMC7465284/ /pubmed/32764270 http://dx.doi.org/10.3390/jcm9082521 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fontaine, Candice
Jacq, Gwenaelle
Perier, François
Holleville, Mathilde
Legriel, Stephane
The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review
title The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review
title_full The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review
title_fullStr The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review
title_full_unstemmed The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review
title_short The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review
title_sort role of secondary brain insults in status epilepticus: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465284/
https://www.ncbi.nlm.nih.gov/pubmed/32764270
http://dx.doi.org/10.3390/jcm9082521
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