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Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children

Little is known about the causes and the frequency of meningitis and encephalitis in Poland. We did a retrospective single-center cohort study of children under 18 years old hospitalized with infectious meningitis or encephalitis. Incidence rates were calculated using collected data from patients fr...

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Autores principales: Toczylowski, Kacper, Bojkiewicz, Ewa, Barszcz, Marta, Wozinska-Klepadlo, Marta, Potocka, Paulina, Sulik, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465305/
https://www.ncbi.nlm.nih.gov/pubmed/32707777
http://dx.doi.org/10.3390/jcm9082324
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author Toczylowski, Kacper
Bojkiewicz, Ewa
Barszcz, Marta
Wozinska-Klepadlo, Marta
Potocka, Paulina
Sulik, Artur
author_facet Toczylowski, Kacper
Bojkiewicz, Ewa
Barszcz, Marta
Wozinska-Klepadlo, Marta
Potocka, Paulina
Sulik, Artur
author_sort Toczylowski, Kacper
collection PubMed
description Little is known about the causes and the frequency of meningitis and encephalitis in Poland. We did a retrospective single-center cohort study of children under 18 years old hospitalized with infectious meningitis or encephalitis. Incidence rates were calculated using collected data from patients from the North-East Poland only. A total of 374 children hospitalized between 1 January 2015 and 31 December 2019 were included in the study. A total of 332 (89%) children had meningitis, and 42 (11%) had encephalitis. The etiology of the infection was established in 331 (89%) cases. Enteroviruses accounted for 224 (60%) of all patients. A total of 68 (18%) cases were tick-borne infections. Bacterial pathogens were detected in 26 (7%) children. The median length of hospital stay for children with enteroviral meningitis was 7 days (IQR 7–9), increasing to 11 days (8–13) in those treated with antibiotics. The incidence of meningitis was estimated to be 32.22 (95% CI, 25.33–40.98) per 100,000 and that of encephalitis to be 4.08 (95% CI, 2.07–8.02) per 100,000. By the broad use of molecular diagnostic methods, we managed to identify etiology of the infection in the majority of children. Our data suggest that thorough diagnostics of central nervous system infections are needed to rationalize treatment.
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spelling pubmed-74653052020-09-04 Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children Toczylowski, Kacper Bojkiewicz, Ewa Barszcz, Marta Wozinska-Klepadlo, Marta Potocka, Paulina Sulik, Artur J Clin Med Article Little is known about the causes and the frequency of meningitis and encephalitis in Poland. We did a retrospective single-center cohort study of children under 18 years old hospitalized with infectious meningitis or encephalitis. Incidence rates were calculated using collected data from patients from the North-East Poland only. A total of 374 children hospitalized between 1 January 2015 and 31 December 2019 were included in the study. A total of 332 (89%) children had meningitis, and 42 (11%) had encephalitis. The etiology of the infection was established in 331 (89%) cases. Enteroviruses accounted for 224 (60%) of all patients. A total of 68 (18%) cases were tick-borne infections. Bacterial pathogens were detected in 26 (7%) children. The median length of hospital stay for children with enteroviral meningitis was 7 days (IQR 7–9), increasing to 11 days (8–13) in those treated with antibiotics. The incidence of meningitis was estimated to be 32.22 (95% CI, 25.33–40.98) per 100,000 and that of encephalitis to be 4.08 (95% CI, 2.07–8.02) per 100,000. By the broad use of molecular diagnostic methods, we managed to identify etiology of the infection in the majority of children. Our data suggest that thorough diagnostics of central nervous system infections are needed to rationalize treatment. MDPI 2020-07-22 /pmc/articles/PMC7465305/ /pubmed/32707777 http://dx.doi.org/10.3390/jcm9082324 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Toczylowski, Kacper
Bojkiewicz, Ewa
Barszcz, Marta
Wozinska-Klepadlo, Marta
Potocka, Paulina
Sulik, Artur
Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children
title Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children
title_full Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children
title_fullStr Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children
title_full_unstemmed Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children
title_short Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children
title_sort etiology, clinical presentation and incidence of infectious meningitis and encephalitis in polish children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465305/
https://www.ncbi.nlm.nih.gov/pubmed/32707777
http://dx.doi.org/10.3390/jcm9082324
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