Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms

BACKGROUND: Several genetic alterations, including point mutations and copy number variations in NLGN genes, have been associated with psychiatric disorders, such as autism spectrum disorder (ASD) and X-linked mental retardation (XLMR). NLGN genes encode neuroligin (NL) proteins, which are adhesion...

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Detalles Bibliográficos
Autores principales: Yumoto, Takafumi, Kimura, Misaki, Nagatomo, Ryota, Sato, Tsukika, Utsunomiya, Shun, Aoki, Natsue, Kitaura, Motoji, Takahashi, Koji, Takemoto, Hiroshi, Watanabe, Hirotaka, Okano, Hideyuki, Yoshida, Fumiaki, Nao, Yosuke, Tomita, Taisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465329/
https://www.ncbi.nlm.nih.gov/pubmed/32873342
http://dx.doi.org/10.1186/s13229-020-00373-y

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