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Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea
To fight reactive oxygen species (ROS) produced by both the metabolism and strongly oxidative habitats, hyperthermophilic archaea are equipped with an array of antioxidant enzymes whose role is to protect the biological macromolecules from oxidative damage. The most common ROS, such as superoxide ra...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465337/ https://www.ncbi.nlm.nih.gov/pubmed/32756530 http://dx.doi.org/10.3390/antiox9080703 |
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author | Pedone, Emilia Fiorentino, Gabriella Bartolucci, Simonetta Limauro, Danila |
author_facet | Pedone, Emilia Fiorentino, Gabriella Bartolucci, Simonetta Limauro, Danila |
author_sort | Pedone, Emilia |
collection | PubMed |
description | To fight reactive oxygen species (ROS) produced by both the metabolism and strongly oxidative habitats, hyperthermophilic archaea are equipped with an array of antioxidant enzymes whose role is to protect the biological macromolecules from oxidative damage. The most common ROS, such as superoxide radical (O(2)(•−)) and hydrogen peroxide (H(2)O(2)), are scavenged by superoxide dismutase, peroxiredoxins, and catalase. These enzymes, together with thioredoxin, protein disulfide oxidoreductase, and thioredoxin reductase, which are involved in redox homeostasis, represent the core of the antioxidant system. In this review, we offer a panorama of progression of knowledge on the antioxidative system in aerobic or microaerobic (hyper)thermophilic archaea and possible industrial applications of these enzymes. |
format | Online Article Text |
id | pubmed-7465337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74653372020-09-04 Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea Pedone, Emilia Fiorentino, Gabriella Bartolucci, Simonetta Limauro, Danila Antioxidants (Basel) Review To fight reactive oxygen species (ROS) produced by both the metabolism and strongly oxidative habitats, hyperthermophilic archaea are equipped with an array of antioxidant enzymes whose role is to protect the biological macromolecules from oxidative damage. The most common ROS, such as superoxide radical (O(2)(•−)) and hydrogen peroxide (H(2)O(2)), are scavenged by superoxide dismutase, peroxiredoxins, and catalase. These enzymes, together with thioredoxin, protein disulfide oxidoreductase, and thioredoxin reductase, which are involved in redox homeostasis, represent the core of the antioxidant system. In this review, we offer a panorama of progression of knowledge on the antioxidative system in aerobic or microaerobic (hyper)thermophilic archaea and possible industrial applications of these enzymes. MDPI 2020-08-03 /pmc/articles/PMC7465337/ /pubmed/32756530 http://dx.doi.org/10.3390/antiox9080703 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pedone, Emilia Fiorentino, Gabriella Bartolucci, Simonetta Limauro, Danila Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea |
title | Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea |
title_full | Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea |
title_fullStr | Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea |
title_full_unstemmed | Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea |
title_short | Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea |
title_sort | enzymatic antioxidant signatures in hyperthermophilic archaea |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465337/ https://www.ncbi.nlm.nih.gov/pubmed/32756530 http://dx.doi.org/10.3390/antiox9080703 |
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