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Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care

Semisolid dosage forms are recommended for the dermal care of babies and children. If we look at the ingredients of these preparations, there are still many cases in which there are substances (occlusive agents, preservatives) that no longer meet certain requirements of the modern age, so it is time...

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Autores principales: Kovács, Anita, Péter-Héderi, Dóra, Perei, Katalin, Budai-Szűcs, Mária, Léber, Attila, Gácsi, Attila, Csányi, Erzsébet, Berkó, Szilvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465361/
https://www.ncbi.nlm.nih.gov/pubmed/32759663
http://dx.doi.org/10.3390/pharmaceutics12080729
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author Kovács, Anita
Péter-Héderi, Dóra
Perei, Katalin
Budai-Szűcs, Mária
Léber, Attila
Gácsi, Attila
Csányi, Erzsébet
Berkó, Szilvia
author_facet Kovács, Anita
Péter-Héderi, Dóra
Perei, Katalin
Budai-Szűcs, Mária
Léber, Attila
Gácsi, Attila
Csányi, Erzsébet
Berkó, Szilvia
author_sort Kovács, Anita
collection PubMed
description Semisolid dosage forms are recommended for the dermal care of babies and children. If we look at the ingredients of these preparations, there are still many cases in which there are substances (occlusive agents, preservatives) that no longer meet certain requirements of the modern age, so it is timely to replace them with other substances. The aim of this work was to formulate a science-based formulation with new components that keep or improve its moisturizing properties, rheological parameters, and microbiological stability. Occlusive oils, like white petrolatum and liquid paraffin and the preservative parabens are traditional ingredients in oil in water creams, were replaced with white beeswax, sunflower oil, and phenoxyethanol, respectively. Cocoa butter, urea, and glycerol were added to improve long-lasting hydration and support the barrier function of the reformulated creams. The rheological properties of the formulations were determined. The effects of the preparations on skin hydration and on the barrier function of the skin were tested. Furthermore, microbiological stability was investigated. The result of the reformulation was an o/w cream that provided a good longer-lasting hydration effect; supported the barrier function of the baby skin without occlusion; and had adequate consistency, easy spreading, a pleasant skin feeling, proper pH, and good microbiological stability.
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spelling pubmed-74653612020-09-04 Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care Kovács, Anita Péter-Héderi, Dóra Perei, Katalin Budai-Szűcs, Mária Léber, Attila Gácsi, Attila Csányi, Erzsébet Berkó, Szilvia Pharmaceutics Article Semisolid dosage forms are recommended for the dermal care of babies and children. If we look at the ingredients of these preparations, there are still many cases in which there are substances (occlusive agents, preservatives) that no longer meet certain requirements of the modern age, so it is timely to replace them with other substances. The aim of this work was to formulate a science-based formulation with new components that keep or improve its moisturizing properties, rheological parameters, and microbiological stability. Occlusive oils, like white petrolatum and liquid paraffin and the preservative parabens are traditional ingredients in oil in water creams, were replaced with white beeswax, sunflower oil, and phenoxyethanol, respectively. Cocoa butter, urea, and glycerol were added to improve long-lasting hydration and support the barrier function of the reformulated creams. The rheological properties of the formulations were determined. The effects of the preparations on skin hydration and on the barrier function of the skin were tested. Furthermore, microbiological stability was investigated. The result of the reformulation was an o/w cream that provided a good longer-lasting hydration effect; supported the barrier function of the baby skin without occlusion; and had adequate consistency, easy spreading, a pleasant skin feeling, proper pH, and good microbiological stability. MDPI 2020-08-04 /pmc/articles/PMC7465361/ /pubmed/32759663 http://dx.doi.org/10.3390/pharmaceutics12080729 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kovács, Anita
Péter-Héderi, Dóra
Perei, Katalin
Budai-Szűcs, Mária
Léber, Attila
Gácsi, Attila
Csányi, Erzsébet
Berkó, Szilvia
Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
title Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
title_full Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
title_fullStr Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
title_full_unstemmed Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
title_short Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
title_sort effects of formulation excipients on skin barrier function in creams used in pediatric care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465361/
https://www.ncbi.nlm.nih.gov/pubmed/32759663
http://dx.doi.org/10.3390/pharmaceutics12080729
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