The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Businello, Gianluca, Parente, Paola, Mastracci, Luca, Pennelli, Gianmaria, Traverso, Giulia, Milione, Massimo, Bellan, Elena, Michelotto, Mauro, Kotsafti, Andromachi, Grillo, Federica, Fassan, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465394/
https://www.ncbi.nlm.nih.gov/pubmed/32759723
http://dx.doi.org/10.3390/cancers12082160
_version_ 1783577578127228928
author Businello, Gianluca
Parente, Paola
Mastracci, Luca
Pennelli, Gianmaria
Traverso, Giulia
Milione, Massimo
Bellan, Elena
Michelotto, Mauro
Kotsafti, Andromachi
Grillo, Federica
Fassan, Matteo
author_facet Businello, Gianluca
Parente, Paola
Mastracci, Luca
Pennelli, Gianmaria
Traverso, Giulia
Milione, Massimo
Bellan, Elena
Michelotto, Mauro
Kotsafti, Andromachi
Grillo, Federica
Fassan, Matteo
author_sort Businello, Gianluca
collection PubMed
description Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
format Online
Article
Text
id pubmed-7465394
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74653942020-09-04 The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis Businello, Gianluca Parente, Paola Mastracci, Luca Pennelli, Gianmaria Traverso, Giulia Milione, Massimo Bellan, Elena Michelotto, Mauro Kotsafti, Andromachi Grillo, Federica Fassan, Matteo Cancers (Basel) Review Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas. MDPI 2020-08-04 /pmc/articles/PMC7465394/ /pubmed/32759723 http://dx.doi.org/10.3390/cancers12082160 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Businello, Gianluca
Parente, Paola
Mastracci, Luca
Pennelli, Gianmaria
Traverso, Giulia
Milione, Massimo
Bellan, Elena
Michelotto, Mauro
Kotsafti, Andromachi
Grillo, Federica
Fassan, Matteo
The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
title The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
title_full The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
title_fullStr The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
title_full_unstemmed The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
title_short The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
title_sort pathologic and molecular landscape of esophageal squamous cell carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465394/
https://www.ncbi.nlm.nih.gov/pubmed/32759723
http://dx.doi.org/10.3390/cancers12082160
work_keys_str_mv AT businellogianluca thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT parentepaola thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT mastracciluca thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT pennelligianmaria thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT traversogiulia thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT milionemassimo thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT bellanelena thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT michelottomauro thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT kotsaftiandromachi thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT grillofederica thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT fassanmatteo thepathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT businellogianluca pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT parentepaola pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT mastracciluca pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT pennelligianmaria pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT traversogiulia pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT milionemassimo pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT bellanelena pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT michelottomauro pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT kotsaftiandromachi pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT grillofederica pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis
AT fassanmatteo pathologicandmolecularlandscapeofesophagealsquamouscellcarcinogenesis

Ejemplares similares