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SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
In the coronavirus disease (COVID-19) pandemic, cancer patients could be a high-risk group due to their immunosuppressed status; therefore, data on cancer patients must be available in order to consider the most adequate strategy of care. We carried out a cohort study on the risk of hospitalization...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465442/ https://www.ncbi.nlm.nih.gov/pubmed/32707770 http://dx.doi.org/10.3390/biology9080181 |
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author | Pinto, Carmine Berselli, Annalisa Mangone, Lucia Damato, Angela Iachetta, Francesco Foracchia, Marco Zanelli, Francesca Gervasi, Erika Romagnani, Alessandra Prati, Giuseppe Lui, Stefania Venturelli, Francesco Vicentini, Massimo Besutti, Giulia De Palma, Rossana Giorgi Rossi, Paolo |
author_facet | Pinto, Carmine Berselli, Annalisa Mangone, Lucia Damato, Angela Iachetta, Francesco Foracchia, Marco Zanelli, Francesca Gervasi, Erika Romagnani, Alessandra Prati, Giuseppe Lui, Stefania Venturelli, Francesco Vicentini, Massimo Besutti, Giulia De Palma, Rossana Giorgi Rossi, Paolo |
author_sort | Pinto, Carmine |
collection | PubMed |
description | In the coronavirus disease (COVID-19) pandemic, cancer patients could be a high-risk group due to their immunosuppressed status; therefore, data on cancer patients must be available in order to consider the most adequate strategy of care. We carried out a cohort study on the risk of hospitalization for COVID-19, oncological history, and outcomes on COVID-19 infected cancer patients admitted to the Hospital of Reggio Emilia. Between 1 February and 3 April 2020, a total of 1226 COVID-19 infected patients were hospitalized. The number of cancer patients hospitalized with COVID-19 infection was 138 (11.3%). The median age was slightly higher in patients with cancers than in those without (76.5 vs. 73.0). The risk of intensive care unit (ICU) admission (10.1% vs. 6.7%; RR 1.23, 95% Confidence Interval (CI) 0.63–2.41) and risk of death (34.1% vs. 26.0%; RR 1.07, 95% CI 0.61–1.71) were similar in cancer and non-cancer patients. In the cancer patients group, 89/138 (64.5%) patients had a time interval >5 years between the diagnosis of the tumor and hospitalization. Male gender, age > 74 years, metastatic disease, bladder cancer, and cardiovascular disease were associated with mortality risk in cancer patients. In the Reggio Emilia Study, the incidence of hospitalization for COVID-19 in people with previous diagnosis of cancer is similar to that in the general population (standardized incidence ratio 98; 95% CI 73–131), and it does not appear to have a more severe course or a higher mortality rate than patients without cancer. The phase II of the COVID-19 epidemic in cancer patients needs a strategy to reduce the likelihood of infection and identify the vulnerable population, both in patients with active antineoplastic treatment and in survivors with frequently different coexisting medical conditions. |
format | Online Article Text |
id | pubmed-7465442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74654422020-09-04 SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia Pinto, Carmine Berselli, Annalisa Mangone, Lucia Damato, Angela Iachetta, Francesco Foracchia, Marco Zanelli, Francesca Gervasi, Erika Romagnani, Alessandra Prati, Giuseppe Lui, Stefania Venturelli, Francesco Vicentini, Massimo Besutti, Giulia De Palma, Rossana Giorgi Rossi, Paolo Biology (Basel) Article In the coronavirus disease (COVID-19) pandemic, cancer patients could be a high-risk group due to their immunosuppressed status; therefore, data on cancer patients must be available in order to consider the most adequate strategy of care. We carried out a cohort study on the risk of hospitalization for COVID-19, oncological history, and outcomes on COVID-19 infected cancer patients admitted to the Hospital of Reggio Emilia. Between 1 February and 3 April 2020, a total of 1226 COVID-19 infected patients were hospitalized. The number of cancer patients hospitalized with COVID-19 infection was 138 (11.3%). The median age was slightly higher in patients with cancers than in those without (76.5 vs. 73.0). The risk of intensive care unit (ICU) admission (10.1% vs. 6.7%; RR 1.23, 95% Confidence Interval (CI) 0.63–2.41) and risk of death (34.1% vs. 26.0%; RR 1.07, 95% CI 0.61–1.71) were similar in cancer and non-cancer patients. In the cancer patients group, 89/138 (64.5%) patients had a time interval >5 years between the diagnosis of the tumor and hospitalization. Male gender, age > 74 years, metastatic disease, bladder cancer, and cardiovascular disease were associated with mortality risk in cancer patients. In the Reggio Emilia Study, the incidence of hospitalization for COVID-19 in people with previous diagnosis of cancer is similar to that in the general population (standardized incidence ratio 98; 95% CI 73–131), and it does not appear to have a more severe course or a higher mortality rate than patients without cancer. The phase II of the COVID-19 epidemic in cancer patients needs a strategy to reduce the likelihood of infection and identify the vulnerable population, both in patients with active antineoplastic treatment and in survivors with frequently different coexisting medical conditions. MDPI 2020-07-22 /pmc/articles/PMC7465442/ /pubmed/32707770 http://dx.doi.org/10.3390/biology9080181 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pinto, Carmine Berselli, Annalisa Mangone, Lucia Damato, Angela Iachetta, Francesco Foracchia, Marco Zanelli, Francesca Gervasi, Erika Romagnani, Alessandra Prati, Giuseppe Lui, Stefania Venturelli, Francesco Vicentini, Massimo Besutti, Giulia De Palma, Rossana Giorgi Rossi, Paolo SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia |
title | SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia |
title_full | SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia |
title_fullStr | SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia |
title_full_unstemmed | SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia |
title_short | SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia |
title_sort | sars-cov-2 positive hospitalized cancer patients during the italian outbreak: the cohort study in reggio emilia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465442/ https://www.ncbi.nlm.nih.gov/pubmed/32707770 http://dx.doi.org/10.3390/biology9080181 |
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