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SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia

In the coronavirus disease (COVID-19) pandemic, cancer patients could be a high-risk group due to their immunosuppressed status; therefore, data on cancer patients must be available in order to consider the most adequate strategy of care. We carried out a cohort study on the risk of hospitalization...

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Autores principales: Pinto, Carmine, Berselli, Annalisa, Mangone, Lucia, Damato, Angela, Iachetta, Francesco, Foracchia, Marco, Zanelli, Francesca, Gervasi, Erika, Romagnani, Alessandra, Prati, Giuseppe, Lui, Stefania, Venturelli, Francesco, Vicentini, Massimo, Besutti, Giulia, De Palma, Rossana, Giorgi Rossi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465442/
https://www.ncbi.nlm.nih.gov/pubmed/32707770
http://dx.doi.org/10.3390/biology9080181
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author Pinto, Carmine
Berselli, Annalisa
Mangone, Lucia
Damato, Angela
Iachetta, Francesco
Foracchia, Marco
Zanelli, Francesca
Gervasi, Erika
Romagnani, Alessandra
Prati, Giuseppe
Lui, Stefania
Venturelli, Francesco
Vicentini, Massimo
Besutti, Giulia
De Palma, Rossana
Giorgi Rossi, Paolo
author_facet Pinto, Carmine
Berselli, Annalisa
Mangone, Lucia
Damato, Angela
Iachetta, Francesco
Foracchia, Marco
Zanelli, Francesca
Gervasi, Erika
Romagnani, Alessandra
Prati, Giuseppe
Lui, Stefania
Venturelli, Francesco
Vicentini, Massimo
Besutti, Giulia
De Palma, Rossana
Giorgi Rossi, Paolo
author_sort Pinto, Carmine
collection PubMed
description In the coronavirus disease (COVID-19) pandemic, cancer patients could be a high-risk group due to their immunosuppressed status; therefore, data on cancer patients must be available in order to consider the most adequate strategy of care. We carried out a cohort study on the risk of hospitalization for COVID-19, oncological history, and outcomes on COVID-19 infected cancer patients admitted to the Hospital of Reggio Emilia. Between 1 February and 3 April 2020, a total of 1226 COVID-19 infected patients were hospitalized. The number of cancer patients hospitalized with COVID-19 infection was 138 (11.3%). The median age was slightly higher in patients with cancers than in those without (76.5 vs. 73.0). The risk of intensive care unit (ICU) admission (10.1% vs. 6.7%; RR 1.23, 95% Confidence Interval (CI) 0.63–2.41) and risk of death (34.1% vs. 26.0%; RR 1.07, 95% CI 0.61–1.71) were similar in cancer and non-cancer patients. In the cancer patients group, 89/138 (64.5%) patients had a time interval >5 years between the diagnosis of the tumor and hospitalization. Male gender, age > 74 years, metastatic disease, bladder cancer, and cardiovascular disease were associated with mortality risk in cancer patients. In the Reggio Emilia Study, the incidence of hospitalization for COVID-19 in people with previous diagnosis of cancer is similar to that in the general population (standardized incidence ratio 98; 95% CI 73–131), and it does not appear to have a more severe course or a higher mortality rate than patients without cancer. The phase II of the COVID-19 epidemic in cancer patients needs a strategy to reduce the likelihood of infection and identify the vulnerable population, both in patients with active antineoplastic treatment and in survivors with frequently different coexisting medical conditions.
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spelling pubmed-74654422020-09-04 SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia Pinto, Carmine Berselli, Annalisa Mangone, Lucia Damato, Angela Iachetta, Francesco Foracchia, Marco Zanelli, Francesca Gervasi, Erika Romagnani, Alessandra Prati, Giuseppe Lui, Stefania Venturelli, Francesco Vicentini, Massimo Besutti, Giulia De Palma, Rossana Giorgi Rossi, Paolo Biology (Basel) Article In the coronavirus disease (COVID-19) pandemic, cancer patients could be a high-risk group due to their immunosuppressed status; therefore, data on cancer patients must be available in order to consider the most adequate strategy of care. We carried out a cohort study on the risk of hospitalization for COVID-19, oncological history, and outcomes on COVID-19 infected cancer patients admitted to the Hospital of Reggio Emilia. Between 1 February and 3 April 2020, a total of 1226 COVID-19 infected patients were hospitalized. The number of cancer patients hospitalized with COVID-19 infection was 138 (11.3%). The median age was slightly higher in patients with cancers than in those without (76.5 vs. 73.0). The risk of intensive care unit (ICU) admission (10.1% vs. 6.7%; RR 1.23, 95% Confidence Interval (CI) 0.63–2.41) and risk of death (34.1% vs. 26.0%; RR 1.07, 95% CI 0.61–1.71) were similar in cancer and non-cancer patients. In the cancer patients group, 89/138 (64.5%) patients had a time interval >5 years between the diagnosis of the tumor and hospitalization. Male gender, age > 74 years, metastatic disease, bladder cancer, and cardiovascular disease were associated with mortality risk in cancer patients. In the Reggio Emilia Study, the incidence of hospitalization for COVID-19 in people with previous diagnosis of cancer is similar to that in the general population (standardized incidence ratio 98; 95% CI 73–131), and it does not appear to have a more severe course or a higher mortality rate than patients without cancer. The phase II of the COVID-19 epidemic in cancer patients needs a strategy to reduce the likelihood of infection and identify the vulnerable population, both in patients with active antineoplastic treatment and in survivors with frequently different coexisting medical conditions. MDPI 2020-07-22 /pmc/articles/PMC7465442/ /pubmed/32707770 http://dx.doi.org/10.3390/biology9080181 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pinto, Carmine
Berselli, Annalisa
Mangone, Lucia
Damato, Angela
Iachetta, Francesco
Foracchia, Marco
Zanelli, Francesca
Gervasi, Erika
Romagnani, Alessandra
Prati, Giuseppe
Lui, Stefania
Venturelli, Francesco
Vicentini, Massimo
Besutti, Giulia
De Palma, Rossana
Giorgi Rossi, Paolo
SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
title SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
title_full SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
title_fullStr SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
title_full_unstemmed SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
title_short SARS-CoV-2 Positive Hospitalized Cancer Patients during the Italian Outbreak: The Cohort Study in Reggio Emilia
title_sort sars-cov-2 positive hospitalized cancer patients during the italian outbreak: the cohort study in reggio emilia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465442/
https://www.ncbi.nlm.nih.gov/pubmed/32707770
http://dx.doi.org/10.3390/biology9080181
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