Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53’s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption

Arecoline is the principal alkaloid in the areca nut, a component of betel quids (BQs), which are carcinogenic to humans. Epidemiological studies indicate that BQ-chewing contributes to the occurrence of head and neck cancer (HNC). Previously, we have reported that arecoline (0.3 mM) is able to inhi...

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Detalles Bibliográficos
Autores principales: Wang, Yu-Chu, Huang, Jau-Ling, Lee, Ka-Wo, Lu, Hsing-Han, Lin, Yuan-Jen, Chen, Long-Fong, Wang, Chung-Sheng, Cheng, Yun-Chiao, Zeng, Zih-Ting, Chu, Pei-Yi, Lin, Chang-Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465463/
https://www.ncbi.nlm.nih.gov/pubmed/32722430
http://dx.doi.org/10.3390/cancers12082053

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