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Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions

Structural changes in the hippocampus and amygdala have been demonstrated in schizophrenia patients. However, whether morphological information from these subcortical regions could be used by machine learning algorithms for schizophrenia classification were unknown. The aim of this study was to use...

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Detalles Bibliográficos
Autores principales: Guo, Yingying, Qiu, Jianfeng, Lu, Weizhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465509/
https://www.ncbi.nlm.nih.gov/pubmed/32824267
http://dx.doi.org/10.3390/brainsci10080562
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author Guo, Yingying
Qiu, Jianfeng
Lu, Weizhao
author_facet Guo, Yingying
Qiu, Jianfeng
Lu, Weizhao
author_sort Guo, Yingying
collection PubMed
description Structural changes in the hippocampus and amygdala have been demonstrated in schizophrenia patients. However, whether morphological information from these subcortical regions could be used by machine learning algorithms for schizophrenia classification were unknown. The aim of this study was to use volume of the amygdaloid and hippocampal subregions for schizophrenia classification. The dataset consisted of 57 patients with schizophrenia and 69 healthy controls. The volume of 26 hippocampal and 20 amygdaloid subregions were extracted from T1 structural MRI images. Sequential backward elimination (SBE) algorithm was used for feature selection, and a linear support vector machine (SVM) classifier was configured to explore the feasibility of hippocampal and amygdaloid subregions in the classification of schizophrenia. The proposed SBE-SVM model achieved a classification accuracy of 81.75% on 57 patients and 69 healthy controls, with a sensitivity of 84.21% and a specificity of 81.16%. AUC was 0.8241 (p < 0.001 tested with 1000-times permutation). The results demonstrated evidence of hippocampal and amygdaloid structural changes in schizophrenia patients, and also suggested that morphological features from the amygdaloid and hippocampal subregions could be used by machine learning algorithms for the classification of schizophrenia.
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spelling pubmed-74655092020-09-04 Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions Guo, Yingying Qiu, Jianfeng Lu, Weizhao Brain Sci Article Structural changes in the hippocampus and amygdala have been demonstrated in schizophrenia patients. However, whether morphological information from these subcortical regions could be used by machine learning algorithms for schizophrenia classification were unknown. The aim of this study was to use volume of the amygdaloid and hippocampal subregions for schizophrenia classification. The dataset consisted of 57 patients with schizophrenia and 69 healthy controls. The volume of 26 hippocampal and 20 amygdaloid subregions were extracted from T1 structural MRI images. Sequential backward elimination (SBE) algorithm was used for feature selection, and a linear support vector machine (SVM) classifier was configured to explore the feasibility of hippocampal and amygdaloid subregions in the classification of schizophrenia. The proposed SBE-SVM model achieved a classification accuracy of 81.75% on 57 patients and 69 healthy controls, with a sensitivity of 84.21% and a specificity of 81.16%. AUC was 0.8241 (p < 0.001 tested with 1000-times permutation). The results demonstrated evidence of hippocampal and amygdaloid structural changes in schizophrenia patients, and also suggested that morphological features from the amygdaloid and hippocampal subregions could be used by machine learning algorithms for the classification of schizophrenia. MDPI 2020-08-15 /pmc/articles/PMC7465509/ /pubmed/32824267 http://dx.doi.org/10.3390/brainsci10080562 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Yingying
Qiu, Jianfeng
Lu, Weizhao
Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions
title Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions
title_full Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions
title_fullStr Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions
title_full_unstemmed Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions
title_short Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions
title_sort support vector machine-based schizophrenia classification using morphological information from amygdaloid and hippocampal subregions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465509/
https://www.ncbi.nlm.nih.gov/pubmed/32824267
http://dx.doi.org/10.3390/brainsci10080562
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