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Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?

Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogen...

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Autores principales: Chew, Siang-Siang, Tan, Loh Teng-Hern, Law, Jodi Woan-Fei, Pusparajah, Priyia, Goh, Bey-Hing, Ab Mutalib, Nurul Syakima, Lee, Learn-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465663/
https://www.ncbi.nlm.nih.gov/pubmed/32823729
http://dx.doi.org/10.3390/cancers12082272
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author Chew, Siang-Siang
Tan, Loh Teng-Hern
Law, Jodi Woan-Fei
Pusparajah, Priyia
Goh, Bey-Hing
Ab Mutalib, Nurul Syakima
Lee, Learn-Han
author_facet Chew, Siang-Siang
Tan, Loh Teng-Hern
Law, Jodi Woan-Fei
Pusparajah, Priyia
Goh, Bey-Hing
Ab Mutalib, Nurul Syakima
Lee, Learn-Han
author_sort Chew, Siang-Siang
collection PubMed
description Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogenic potentials such as Fusobacterium nucleatum, Escherichia coli and enterotoxigenic Bacteroides fragilis having been found to contribute to CRC development. More recently, it has been shown that initiation of CRC development by these microorganisms requires the formation of biofilms. Gut microbial biofilm forms in the inner colonic mucus layer and is composed of polymicrobial communities. Biofilm results in the redistribution of colonic epithelial cell E-cadherin, increases permeability of the gut and causes a loss of function of the intestinal barrier, all of which enhance intestinal dysbiosis. This literature review aims to compile the various strategies that target these pathogenic biofilms and could potentially play a role in the prevention of CRC. We explore the potential use of natural products, silver nanoparticles, upconverting nanoparticles, thiosalicylate complexes, anti-rheumatic agent (Auranofin), probiotics and quorum-sensing inhibitors as strategies to hinder colon carcinogenesis via targeting colon-associated biofilms.
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spelling pubmed-74656632020-09-04 Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis? Chew, Siang-Siang Tan, Loh Teng-Hern Law, Jodi Woan-Fei Pusparajah, Priyia Goh, Bey-Hing Ab Mutalib, Nurul Syakima Lee, Learn-Han Cancers (Basel) Review Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogenic potentials such as Fusobacterium nucleatum, Escherichia coli and enterotoxigenic Bacteroides fragilis having been found to contribute to CRC development. More recently, it has been shown that initiation of CRC development by these microorganisms requires the formation of biofilms. Gut microbial biofilm forms in the inner colonic mucus layer and is composed of polymicrobial communities. Biofilm results in the redistribution of colonic epithelial cell E-cadherin, increases permeability of the gut and causes a loss of function of the intestinal barrier, all of which enhance intestinal dysbiosis. This literature review aims to compile the various strategies that target these pathogenic biofilms and could potentially play a role in the prevention of CRC. We explore the potential use of natural products, silver nanoparticles, upconverting nanoparticles, thiosalicylate complexes, anti-rheumatic agent (Auranofin), probiotics and quorum-sensing inhibitors as strategies to hinder colon carcinogenesis via targeting colon-associated biofilms. MDPI 2020-08-13 /pmc/articles/PMC7465663/ /pubmed/32823729 http://dx.doi.org/10.3390/cancers12082272 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chew, Siang-Siang
Tan, Loh Teng-Hern
Law, Jodi Woan-Fei
Pusparajah, Priyia
Goh, Bey-Hing
Ab Mutalib, Nurul Syakima
Lee, Learn-Han
Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?
title Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?
title_full Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?
title_fullStr Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?
title_full_unstemmed Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?
title_short Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?
title_sort targeting gut microbial biofilms—a key to hinder colon carcinogenesis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465663/
https://www.ncbi.nlm.nih.gov/pubmed/32823729
http://dx.doi.org/10.3390/cancers12082272
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