The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells

Ischemic heart disease is currently a major cause of mortality and morbidity worldwide. Nevertheless, the actual therapeutic scenario does not target myocardial cell regeneration and consequently, the progression toward the late stage of chronic heart failure is common. Endothelial progenitor cells...

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Autores principales: Perrotta, Fabio, Perna, Angelica, Komici, Klara, Nigro, Ersilia, Mollica, Mariano, D’Agnano, Vito, De Luca, Antonio, Guerra, Germano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465688/
https://www.ncbi.nlm.nih.gov/pubmed/32796767
http://dx.doi.org/10.3390/cells9081886
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author Perrotta, Fabio
Perna, Angelica
Komici, Klara
Nigro, Ersilia
Mollica, Mariano
D’Agnano, Vito
De Luca, Antonio
Guerra, Germano
author_facet Perrotta, Fabio
Perna, Angelica
Komici, Klara
Nigro, Ersilia
Mollica, Mariano
D’Agnano, Vito
De Luca, Antonio
Guerra, Germano
author_sort Perrotta, Fabio
collection PubMed
description Ischemic heart disease is currently a major cause of mortality and morbidity worldwide. Nevertheless, the actual therapeutic scenario does not target myocardial cell regeneration and consequently, the progression toward the late stage of chronic heart failure is common. Endothelial progenitor cells (EPCs) are bone marrow-derived stem cells that contribute to the homeostasis of the endothelial wall in acute and chronic ischemic disease. Calcium modulation and other molecular pathways (NOTCH, VEGFR, and CXCR4) contribute to EPC proliferation and differentiation. The present review provides a summary of EPC biology with a particular focus on the regulatory pathways of EPCs and describes promising applications for cardiovascular cell therapy.
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spelling pubmed-74656882020-09-04 The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells Perrotta, Fabio Perna, Angelica Komici, Klara Nigro, Ersilia Mollica, Mariano D’Agnano, Vito De Luca, Antonio Guerra, Germano Cells Review Ischemic heart disease is currently a major cause of mortality and morbidity worldwide. Nevertheless, the actual therapeutic scenario does not target myocardial cell regeneration and consequently, the progression toward the late stage of chronic heart failure is common. Endothelial progenitor cells (EPCs) are bone marrow-derived stem cells that contribute to the homeostasis of the endothelial wall in acute and chronic ischemic disease. Calcium modulation and other molecular pathways (NOTCH, VEGFR, and CXCR4) contribute to EPC proliferation and differentiation. The present review provides a summary of EPC biology with a particular focus on the regulatory pathways of EPCs and describes promising applications for cardiovascular cell therapy. MDPI 2020-08-11 /pmc/articles/PMC7465688/ /pubmed/32796767 http://dx.doi.org/10.3390/cells9081886 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Perrotta, Fabio
Perna, Angelica
Komici, Klara
Nigro, Ersilia
Mollica, Mariano
D’Agnano, Vito
De Luca, Antonio
Guerra, Germano
The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells
title The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells
title_full The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells
title_fullStr The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells
title_full_unstemmed The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells
title_short The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells
title_sort state of art of regenerative therapy in cardiovascular ischemic disease: biology, signaling pathways, and epigenetics of endothelial progenitor cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465688/
https://www.ncbi.nlm.nih.gov/pubmed/32796767
http://dx.doi.org/10.3390/cells9081886
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