Immune Pathogenesis of COVID-19 Intoxication: Storm or Silence?

Dysregulation of the immune system undoubtedly plays an important and, perhaps, determining role in the COVID-19 pathogenesis. While the main treatment of the COVID-19 intoxication is focused on neutralizing the excessive inflammatory response, it is worth considering an equally significant problem...

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Detalles Bibliográficos
Autores principales: Kiselevskiy, Mikhail, Shubina, Irina, Chikileva, Irina, Sitdikova, Suria, Samoylenko, Igor, Anisimova, Natalia, Kirgizov, Kirill, Suleimanova, Amina, Gorbunova, Tatyana, Varfolomeeva, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465708/
https://www.ncbi.nlm.nih.gov/pubmed/32722596
http://dx.doi.org/10.3390/ph13080166
Descripción
Sumario:Dysregulation of the immune system undoubtedly plays an important and, perhaps, determining role in the COVID-19 pathogenesis. While the main treatment of the COVID-19 intoxication is focused on neutralizing the excessive inflammatory response, it is worth considering an equally significant problem of the immunosuppressive conditions including immuno-paralysis, which lead to the secondary infection. Therefore, choosing a treatment strategy for the immune-mediated complications of coronavirus infection, one has to pass between Scylla and Charybdis, so that, in the fight against the “cytokine storm,” it is vital not to miss the point of the immune silence that turns into immuno-paralysis.

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