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Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control

Glycated hemoglobin monitorization could be a tool for maintaining type 2 diabetes (T2D) under control and delaying the appearance of cardiovascular events. This cross-sectional study was designed to assess the role of glycemic control in modulating early-stage markers of cardiovascular complication...

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Autores principales: de Marañón, Aranzazu Martinez, Iannantuoni, Francesca, Abad-Jiménez, Zaida, Canet, Francisco, Díaz-Pozo, Pedro, López-Domènech, Sandra, Roldán-Torres, Ildefonso, Morillas, Carlos, Rocha, Milagros, Víctor, Víctor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465892/
https://www.ncbi.nlm.nih.gov/pubmed/32764458
http://dx.doi.org/10.3390/jcm9082522
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author de Marañón, Aranzazu Martinez
Iannantuoni, Francesca
Abad-Jiménez, Zaida
Canet, Francisco
Díaz-Pozo, Pedro
López-Domènech, Sandra
Roldán-Torres, Ildefonso
Morillas, Carlos
Rocha, Milagros
Víctor, Víctor M.
author_facet de Marañón, Aranzazu Martinez
Iannantuoni, Francesca
Abad-Jiménez, Zaida
Canet, Francisco
Díaz-Pozo, Pedro
López-Domènech, Sandra
Roldán-Torres, Ildefonso
Morillas, Carlos
Rocha, Milagros
Víctor, Víctor M.
author_sort de Marañón, Aranzazu Martinez
collection PubMed
description Glycated hemoglobin monitorization could be a tool for maintaining type 2 diabetes (T2D) under control and delaying the appearance of cardiovascular events. This cross-sectional study was designed to assess the role of glycemic control in modulating early-stage markers of cardiovascular complications. One hundred and eight healthy controls and 161 type 2 diabetic patients were recruited and distributed according to their glycemic control, setting the threshold at 6.5% (good control). Biochemical and anthropometrical parameters were registered during the initial visit, and peripheral blood was extracted to obtain polymorphonuclear cells and analyze inflammatory markers, adhesion molecules, leukocyte–endothelium interactions, and carotid intima–media thickness. Correlations between these parameters were explored. We found that inflammatory markers and adhesion molecules were augmented in type 2 diabetic subjects with poor glycemic control. Polymorphonuclear leukocytes interacted more with the endothelium in the diabetic population, and even more significantly in the poorly controlled subjects. In parallel, carotid intima–media thickness was also increased in the diabetic population, and the difference was greater among poorly controlled subjects. Finally, correlation measurement revealed that carotid intima–media thickness was related to glycemic control and lipid metabolism in diabetic patients. Our results suggest that glycemic control delays the onset of cardiovascular comorbidities in diabetic subjects.
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spelling pubmed-74658922020-09-04 Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control de Marañón, Aranzazu Martinez Iannantuoni, Francesca Abad-Jiménez, Zaida Canet, Francisco Díaz-Pozo, Pedro López-Domènech, Sandra Roldán-Torres, Ildefonso Morillas, Carlos Rocha, Milagros Víctor, Víctor M. J Clin Med Article Glycated hemoglobin monitorization could be a tool for maintaining type 2 diabetes (T2D) under control and delaying the appearance of cardiovascular events. This cross-sectional study was designed to assess the role of glycemic control in modulating early-stage markers of cardiovascular complications. One hundred and eight healthy controls and 161 type 2 diabetic patients were recruited and distributed according to their glycemic control, setting the threshold at 6.5% (good control). Biochemical and anthropometrical parameters were registered during the initial visit, and peripheral blood was extracted to obtain polymorphonuclear cells and analyze inflammatory markers, adhesion molecules, leukocyte–endothelium interactions, and carotid intima–media thickness. Correlations between these parameters were explored. We found that inflammatory markers and adhesion molecules were augmented in type 2 diabetic subjects with poor glycemic control. Polymorphonuclear leukocytes interacted more with the endothelium in the diabetic population, and even more significantly in the poorly controlled subjects. In parallel, carotid intima–media thickness was also increased in the diabetic population, and the difference was greater among poorly controlled subjects. Finally, correlation measurement revealed that carotid intima–media thickness was related to glycemic control and lipid metabolism in diabetic patients. Our results suggest that glycemic control delays the onset of cardiovascular comorbidities in diabetic subjects. MDPI 2020-08-05 /pmc/articles/PMC7465892/ /pubmed/32764458 http://dx.doi.org/10.3390/jcm9082522 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Marañón, Aranzazu Martinez
Iannantuoni, Francesca
Abad-Jiménez, Zaida
Canet, Francisco
Díaz-Pozo, Pedro
López-Domènech, Sandra
Roldán-Torres, Ildefonso
Morillas, Carlos
Rocha, Milagros
Víctor, Víctor M.
Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
title Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
title_full Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
title_fullStr Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
title_full_unstemmed Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
title_short Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
title_sort association between proinflammatory markers, leukocyte–endothelium interactions, and carotid intima–media thickness in type 2 diabetes: role of glycemic control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465892/
https://www.ncbi.nlm.nih.gov/pubmed/32764458
http://dx.doi.org/10.3390/jcm9082522
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