The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling

Downregulation of the cylindromatosis (CYLD) tumor suppressor has been associated with breast cancer development and progression. Here, we report a critical role for CYLD in maintaining the phenotype of mammary epithelial cells in vitro and in vivo. CYLD downregulation or inactivation induced an epi...

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Detalles Bibliográficos
Autores principales: Pseftogas, Athanasios, Xanthopoulos, Konstantinos, Poutahidis, Theofilos, Ainali, Chrysanthi, Dafou, Dimitra, Panteris, Emmanuel, Kern, Joseph G., Varelas, Xaralabos, Hardas, Alexander, Gonidas, Christos, Tsingotjidou, Anastasia, Hatzivassiliou, Eudoxia, Mosialos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466024/
https://www.ncbi.nlm.nih.gov/pubmed/32722292
http://dx.doi.org/10.3390/cancers12082047

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