BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of misfolded proteins, which then form neurotoxic aggre...

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Detalles Bibliográficos
Autores principales: Lanzillotta, Chiara, Zuliani, Ilaria, Vasavda, Chirag, Snyder, Solomon H., Paul, Bindu D., Perluigi, Marzia, Di Domenico, Fabio, Barone, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466043/
https://www.ncbi.nlm.nih.gov/pubmed/32727065
http://dx.doi.org/10.3390/antiox9080671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466043/
https://www.ncbi.nlm.nih.gov/pubmed/32727065
http://dx.doi.org/10.3390/antiox9080671

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