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The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466081/ https://www.ncbi.nlm.nih.gov/pubmed/32823928 http://dx.doi.org/10.3390/cancers12082280 |
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author | Aldrich, Melissa B. Rasmussen, John C. Fife, Caroline E. Shaitelman, Simona F. Sevick-Muraca, Eva M. |
author_facet | Aldrich, Melissa B. Rasmussen, John C. Fife, Caroline E. Shaitelman, Simona F. Sevick-Muraca, Eva M. |
author_sort | Aldrich, Melissa B. |
collection | PubMed |
description | Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitating functional outcomes. In this review, we describe how cancer metastasis, lymph node dissection, and radiation therapy alter lymphatic function, as visualized by near-infrared fluorescence lymphatic imaging. Using custom gallium arsenide (GaAs)-intensified systems capable of detecting trace amounts of indocyanine green administered repeatedly as lymphatic contrast for longitudinal clinical imaging, we show that lymphatic dysfunction occurs with cancer progression and treatment and is an early, sub-clinical indicator of cancer-acquired lymphedema. We show that early treatment of lymphedema can restore lymphatic function in breast cancer and head and neck cancer patients and survivors. The compilation of these studies provides insights to the critical role that the lymphatics and the immune system play in the etiology of lymphedema and associated co-morbidities. |
format | Online Article Text |
id | pubmed-7466081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74660812020-09-14 The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors Aldrich, Melissa B. Rasmussen, John C. Fife, Caroline E. Shaitelman, Simona F. Sevick-Muraca, Eva M. Cancers (Basel) Review Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitating functional outcomes. In this review, we describe how cancer metastasis, lymph node dissection, and radiation therapy alter lymphatic function, as visualized by near-infrared fluorescence lymphatic imaging. Using custom gallium arsenide (GaAs)-intensified systems capable of detecting trace amounts of indocyanine green administered repeatedly as lymphatic contrast for longitudinal clinical imaging, we show that lymphatic dysfunction occurs with cancer progression and treatment and is an early, sub-clinical indicator of cancer-acquired lymphedema. We show that early treatment of lymphedema can restore lymphatic function in breast cancer and head and neck cancer patients and survivors. The compilation of these studies provides insights to the critical role that the lymphatics and the immune system play in the etiology of lymphedema and associated co-morbidities. MDPI 2020-08-14 /pmc/articles/PMC7466081/ /pubmed/32823928 http://dx.doi.org/10.3390/cancers12082280 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aldrich, Melissa B. Rasmussen, John C. Fife, Caroline E. Shaitelman, Simona F. Sevick-Muraca, Eva M. The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors |
title | The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors |
title_full | The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors |
title_fullStr | The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors |
title_full_unstemmed | The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors |
title_short | The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors |
title_sort | development and treatment of lymphatic dysfunction in cancer patients and survivors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466081/ https://www.ncbi.nlm.nih.gov/pubmed/32823928 http://dx.doi.org/10.3390/cancers12082280 |
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