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The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors

Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitat...

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Autores principales: Aldrich, Melissa B., Rasmussen, John C., Fife, Caroline E., Shaitelman, Simona F., Sevick-Muraca, Eva M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466081/
https://www.ncbi.nlm.nih.gov/pubmed/32823928
http://dx.doi.org/10.3390/cancers12082280
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author Aldrich, Melissa B.
Rasmussen, John C.
Fife, Caroline E.
Shaitelman, Simona F.
Sevick-Muraca, Eva M.
author_facet Aldrich, Melissa B.
Rasmussen, John C.
Fife, Caroline E.
Shaitelman, Simona F.
Sevick-Muraca, Eva M.
author_sort Aldrich, Melissa B.
collection PubMed
description Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitating functional outcomes. In this review, we describe how cancer metastasis, lymph node dissection, and radiation therapy alter lymphatic function, as visualized by near-infrared fluorescence lymphatic imaging. Using custom gallium arsenide (GaAs)-intensified systems capable of detecting trace amounts of indocyanine green administered repeatedly as lymphatic contrast for longitudinal clinical imaging, we show that lymphatic dysfunction occurs with cancer progression and treatment and is an early, sub-clinical indicator of cancer-acquired lymphedema. We show that early treatment of lymphedema can restore lymphatic function in breast cancer and head and neck cancer patients and survivors. The compilation of these studies provides insights to the critical role that the lymphatics and the immune system play in the etiology of lymphedema and associated co-morbidities.
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spelling pubmed-74660812020-09-14 The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors Aldrich, Melissa B. Rasmussen, John C. Fife, Caroline E. Shaitelman, Simona F. Sevick-Muraca, Eva M. Cancers (Basel) Review Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitating functional outcomes. In this review, we describe how cancer metastasis, lymph node dissection, and radiation therapy alter lymphatic function, as visualized by near-infrared fluorescence lymphatic imaging. Using custom gallium arsenide (GaAs)-intensified systems capable of detecting trace amounts of indocyanine green administered repeatedly as lymphatic contrast for longitudinal clinical imaging, we show that lymphatic dysfunction occurs with cancer progression and treatment and is an early, sub-clinical indicator of cancer-acquired lymphedema. We show that early treatment of lymphedema can restore lymphatic function in breast cancer and head and neck cancer patients and survivors. The compilation of these studies provides insights to the critical role that the lymphatics and the immune system play in the etiology of lymphedema and associated co-morbidities. MDPI 2020-08-14 /pmc/articles/PMC7466081/ /pubmed/32823928 http://dx.doi.org/10.3390/cancers12082280 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aldrich, Melissa B.
Rasmussen, John C.
Fife, Caroline E.
Shaitelman, Simona F.
Sevick-Muraca, Eva M.
The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
title The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
title_full The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
title_fullStr The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
title_full_unstemmed The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
title_short The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
title_sort development and treatment of lymphatic dysfunction in cancer patients and survivors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466081/
https://www.ncbi.nlm.nih.gov/pubmed/32823928
http://dx.doi.org/10.3390/cancers12082280
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