Cargando…

Concurrent TP53 and CDKN2A Gene Aberrations in Newly Diagnosed Mantle Cell Lymphoma Correlate with Chemoresistance and Call for Innovative Upfront Therapy

Mantle cell lymphoma (MCL) is a subtype of B-cell lymphoma with a large number of recurrent cytogenetic/molecular aberrations. Approximately 5–10% of patients do not respond to frontline immunochemotherapy. Despite many useful prognostic indexes, a reliable marker of chemoresistance is not available...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malarikova, Diana, Berkova, Adela, Obr, Ales, Blahovcova, Petra, Svaton, Michael, Forsterova, Kristina, Kriegova, Eva, Prihodova, Eva, Pavlistova, Lenka, Petrackova, Anna, Zemanova, Zuzana, Trneny, Marek, Klener, Pavel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466084/ https://www.ncbi.nlm.nih.gov/pubmed/32751805 http://dx.doi.org/10.3390/cancers12082120

Ejemplares similares

Ibrutinib in mantle cell lymphoma: a real-world retrospective multi-center analysis of 77 patients treated in the Czech Republic
por: Obr, Ales, et al.
Publicado: (2022)

Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas
por: Jakša, Radek, et al.
Publicado: (2022)

Differential expression, localization and activity of MARCKS between mantle cell lymphoma and chronic lymphocytic leukemia
por: Vargova, J, et al.
Publicado: (2016)

Resistance-Associated Mutations in Chronic Lymphocytic Leukemia Patients Treated With Novel Agents
por: Sedlarikova, Lenka, et al.
Publicado: (2020)

Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma
por: Klener, Pavel
Publicado: (2019)

PB1750: REARRANGEMENTS OF T-CELL RECEPTOR (TCR) LOCI IN CHILDREN WITH T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
por: Lizcova, L., et al.
Publicado: (2022)

Correction: Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
por: Stepanyan, Ani, et al.
Publicado: (2023)

Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
por: Stepanyan, Ani, et al.
Publicado: (2023)

Diffuse Large B-Cell Lymphoma (DLBCL): Early Patient Management and Emerging Treatment Options
por: Vodicka, Prokop, et al.
Publicado: (2022)

Standardization of Sequencing Coverage Depth in NGS: Recommendation for Detection of Clonal and Subclonal Mutations in Cancer Diagnostics
por: Petrackova, Anna, et al.
Publicado: (2019)

Cross-Disease Innate Gene Signature: Emerging Diversity and Abundance in RA Comparing to SLE and SSc
por: Petrackova, Anna, et al.
Publicado: (2019)

Rare congenital chromosomal aberration dic(X;Y)(p22.33;p11.32) in a patient with primary myelofibrosis
por: Pavlistova, Lenka, et al.
Publicado: (2016)

MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemia
por: Vargova, K, et al.
Publicado: (2017)

Upfront intensive chemo-immunotherapy with autograft in 199 adult mantle cell lymphoma patients: prolonged survival and cure potentiality at long term
por: Cortelazzo, Sergio, et al.
Publicado: (2021)

Intrapleural Bortezomib for the Therapy of Myelomatous Pleural Effusion: A Case Report
por: Klanova, Magdalena, et al.
Publicado: (2012)

Retrospective Analysis of 118 Patients With Cutaneous T-Cell Lymphomas: A Single-Center Experience
por: Polgárová, Kamila, et al.
Publicado: (2022)

The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma
por: Hu, Kuan, et al.
Publicado: (2021)

Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents
por: Klanova, Magdalena, et al.
Publicado: (2014)

Targeting Wnt pathway in mantle cell lymphoma-initiating cells
por: Mathur, Rohit, et al.
Publicado: (2015)

Deregulation of Polycomb Repressive Complex-2 in Mantle Cell Lymphoma Confers Growth Advantage by Epigenetic Suppression of cdkn2b
por: Demosthenous, Christos, et al.
Publicado: (2020)

Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2B
por: Soto, José Luis, et al.
Publicado: (2005)

CDKN1C‐mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib
por: Kagiyama, Yuki, et al.
Publicado: (2021)

Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay
por: Petrackova, Anna, et al.
Publicado: (2017)

Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells
por: Lorkova, Lucie, et al.
Publicado: (2015)

Management of Complete Heart Block in a Pregnant Woman with Systemic Lupus Erythematosus-Associated Complications: Treatment Considerations and Pitfalls
por: Rihackova, Eva, et al.
Publicado: (2022)

DEBATE UPFRONT vs DELAYED TRANSPLANT
por: Gay, F.
Publicado: (2023)

Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57(CDKN1C) and TP53INP1 in mantle cell lymphoma
por: Li, Wei, et al.
Publicado: (2019)

CDYL promotes the chemoresistance of small cell lung cancer by regulating H3K27 trimethylation at the CDKN1C promoter
por: Qiu, Zhengang, et al.
Publicado: (2019)

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection
por: Gallo, Jiri, et al.
Publicado: (2016)

Lenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells
por: Otáhal, Pavel, et al.
Publicado: (2015)

Upfront Daratumumab With Lenalidomide and Dexamethasone for POEMS Syndrome
por: Gavriatopoulou, Maria, et al.
Publicado: (2020)

Surgery for Crohn’s disease: upfront or last resort?
por: Ahmed Ali, U, et al.
Publicado: (2022)

Whole-genome optical mapping of bone-marrow myeloma cells reveals association of extramedullary multiple myeloma with chromosome 1 abnormalities
por: Kriegova, Eva, et al.
Publicado: (2021)

Tackling Mantle Cell Lymphoma in Europe
por: Horgan, Denis, et al.
Publicado: (2022)

The immune microenvironment after neoadjuvant therapy compared to upfront surgery in patients with pancreatic cancer
por: Zwart, Eline S., et al.
Publicado: (2023)

PB2085: UPFRONT TREATMENT OF MANTLE CELL LYMPHOMA (MCL) WITH R-HDAC (RITUXIMAB-HIGH DOSE CYTARABINE + DEXAMETHASONE) IN YOUNG, HIGH RISK PATIENTS IS WELL TOLERATED AND LEADS TO DURABLE RESPONSES.
por: Naylor, G. U., et al.
Publicado: (2022)

Short-term Outcomes After Upfront Chemotherapy Followed by Curative Surgery in Metastatic Colon Cancer: A Comparison With Upfront Surgery Patients
por: Han, Myung Hyun, et al.
Publicado: (2019)

Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma
por: Sircar, Anuvrat, et al.
Publicado: (2023)

Upfront Stereotactic Radiosurgery for Pineal Parenchymal Tumors in Adults
por: Park, Jong Hoon, et al.
Publicado: (2015)

AL AMYLOIDOSIS UPFRONT TREATMENT AND CURRENT AND FUTURE STUDIES
por: Kastritis, E.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ing370aovesm0l0v4h276p4un0