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Involvement of JNK1 in Neuronal Polarization During Brain Development
The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466125/ https://www.ncbi.nlm.nih.gov/pubmed/32823764 http://dx.doi.org/10.3390/cells9081897 |
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author | Castro-Torres, Rubén Darío Busquets, Oriol Parcerisas, Antoni Verdaguer, Ester Olloquequi, Jordi Etchetto, Miren Beas-Zarate, Carlos Folch, Jaume Camins, Antoni Auladell, Carme |
author_facet | Castro-Torres, Rubén Darío Busquets, Oriol Parcerisas, Antoni Verdaguer, Ester Olloquequi, Jordi Etchetto, Miren Beas-Zarate, Carlos Folch, Jaume Camins, Antoni Auladell, Carme |
author_sort | Castro-Torres, Rubén Darío |
collection | PubMed |
description | The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS. |
format | Online Article Text |
id | pubmed-7466125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74661252020-09-14 Involvement of JNK1 in Neuronal Polarization During Brain Development Castro-Torres, Rubén Darío Busquets, Oriol Parcerisas, Antoni Verdaguer, Ester Olloquequi, Jordi Etchetto, Miren Beas-Zarate, Carlos Folch, Jaume Camins, Antoni Auladell, Carme Cells Review The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS. MDPI 2020-08-13 /pmc/articles/PMC7466125/ /pubmed/32823764 http://dx.doi.org/10.3390/cells9081897 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Castro-Torres, Rubén Darío Busquets, Oriol Parcerisas, Antoni Verdaguer, Ester Olloquequi, Jordi Etchetto, Miren Beas-Zarate, Carlos Folch, Jaume Camins, Antoni Auladell, Carme Involvement of JNK1 in Neuronal Polarization During Brain Development |
title | Involvement of JNK1 in Neuronal Polarization During Brain Development |
title_full | Involvement of JNK1 in Neuronal Polarization During Brain Development |
title_fullStr | Involvement of JNK1 in Neuronal Polarization During Brain Development |
title_full_unstemmed | Involvement of JNK1 in Neuronal Polarization During Brain Development |
title_short | Involvement of JNK1 in Neuronal Polarization During Brain Development |
title_sort | involvement of jnk1 in neuronal polarization during brain development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466125/ https://www.ncbi.nlm.nih.gov/pubmed/32823764 http://dx.doi.org/10.3390/cells9081897 |
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