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Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach?
It remains unclear whether the short-term benefits and long-term outcomes of laparoscopic liver resection (LLR) accrue to elderly patients with medical comorbidities. The aim of the present study was to compare the outcomes between LLR and open liver resection (OLR) in elderly patients (≥65 years) w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466133/ https://www.ncbi.nlm.nih.gov/pubmed/32823929 http://dx.doi.org/10.3390/cancers12082281 |
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author | Kim, Jong Man Kim, Sangjin Rhu, Jinsoo Choi, Gyu-Seong Kwon, Choon Hyuck David Joh, Jae-Won |
author_facet | Kim, Jong Man Kim, Sangjin Rhu, Jinsoo Choi, Gyu-Seong Kwon, Choon Hyuck David Joh, Jae-Won |
author_sort | Kim, Jong Man |
collection | PubMed |
description | It remains unclear whether the short-term benefits and long-term outcomes of laparoscopic liver resection (LLR) accrue to elderly patients with medical comorbidities. The aim of the present study was to compare the outcomes between LLR and open liver resection (OLR) in elderly patients (≥65 years) with solitary, treatment-naïve solitary hepatocellular carcinoma (HCC). From January 2013 to August 2017, 256 elderly patients with solitary treatment-naive HCC underwent liver resection. All patients were Child–Pugh class A and older than 65 years. The OLR and LLR groups contained 160 and 96 patients, respectively. The median tumor size in the OLR group was significantly larger than that in the LLR group (3.9 vs. 2.6 cm), but the tumor size did not differ between the two groups after matching. The median operation time, blood loss, transfusion rate, and postoperative complications in the OLR group did not differ from those in the LLR group, but the operation time in the LLR group was longer than that in the OLR group after matching. The median hospitalization in the LLR group was significantly shorter than that in the OLR group. Disease-free survival (DFS) in the LLR group was better than that in the OLR group before and after matching, but the difference was not significant. Patient survival (PS) in the LLR group was similar to that in the OLR group. LLR is feasible and safe for elderly patients with solitary, treatment-naïve HCC. The short- and long-term benefits of LLR are evident in geriatric oncological liver surgery patients. |
format | Online Article Text |
id | pubmed-7466133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74661332020-09-14 Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? Kim, Jong Man Kim, Sangjin Rhu, Jinsoo Choi, Gyu-Seong Kwon, Choon Hyuck David Joh, Jae-Won Cancers (Basel) Article It remains unclear whether the short-term benefits and long-term outcomes of laparoscopic liver resection (LLR) accrue to elderly patients with medical comorbidities. The aim of the present study was to compare the outcomes between LLR and open liver resection (OLR) in elderly patients (≥65 years) with solitary, treatment-naïve solitary hepatocellular carcinoma (HCC). From January 2013 to August 2017, 256 elderly patients with solitary treatment-naive HCC underwent liver resection. All patients were Child–Pugh class A and older than 65 years. The OLR and LLR groups contained 160 and 96 patients, respectively. The median tumor size in the OLR group was significantly larger than that in the LLR group (3.9 vs. 2.6 cm), but the tumor size did not differ between the two groups after matching. The median operation time, blood loss, transfusion rate, and postoperative complications in the OLR group did not differ from those in the LLR group, but the operation time in the LLR group was longer than that in the OLR group after matching. The median hospitalization in the LLR group was significantly shorter than that in the OLR group. Disease-free survival (DFS) in the LLR group was better than that in the OLR group before and after matching, but the difference was not significant. Patient survival (PS) in the LLR group was similar to that in the OLR group. LLR is feasible and safe for elderly patients with solitary, treatment-naïve HCC. The short- and long-term benefits of LLR are evident in geriatric oncological liver surgery patients. MDPI 2020-08-14 /pmc/articles/PMC7466133/ /pubmed/32823929 http://dx.doi.org/10.3390/cancers12082281 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Jong Man Kim, Sangjin Rhu, Jinsoo Choi, Gyu-Seong Kwon, Choon Hyuck David Joh, Jae-Won Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? |
title | Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? |
title_full | Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? |
title_fullStr | Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? |
title_full_unstemmed | Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? |
title_short | Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? |
title_sort | elderly hepatocellular carcinoma patients: open or laparoscopic approach? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466133/ https://www.ncbi.nlm.nih.gov/pubmed/32823929 http://dx.doi.org/10.3390/cancers12082281 |
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