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The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women

Background and Objectives: Metabolic syndrome (MetS) is a multiple risk factor for atherosclerosis, cardiovascular disease, type 2 diabetes and strokes. One-third of middle-age women are at risk of MetS, which predisposes them to type 2 diabetes and cardiovascular disease. Changes in the regulation...

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Autores principales: Schneider-Matyka, Daria, Szkup, Małgorzata, Owczarek, Aleksander Jerzy, Stanisławska, Marzanna, Knyszyńska, Anna, Lubkowska, Anna, Grochans, Elżbieta, Jurczak, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466241/
https://www.ncbi.nlm.nih.gov/pubmed/32751810
http://dx.doi.org/10.3390/medicina56080384
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author Schneider-Matyka, Daria
Szkup, Małgorzata
Owczarek, Aleksander Jerzy
Stanisławska, Marzanna
Knyszyńska, Anna
Lubkowska, Anna
Grochans, Elżbieta
Jurczak, Anna
author_facet Schneider-Matyka, Daria
Szkup, Małgorzata
Owczarek, Aleksander Jerzy
Stanisławska, Marzanna
Knyszyńska, Anna
Lubkowska, Anna
Grochans, Elżbieta
Jurczak, Anna
author_sort Schneider-Matyka, Daria
collection PubMed
description Background and Objectives: Metabolic syndrome (MetS) is a multiple risk factor for atherosclerosis, cardiovascular disease, type 2 diabetes and strokes. One-third of middle-age women are at risk of MetS, which predisposes them to type 2 diabetes and cardiovascular disease. Changes in the regulation of anti-inflammatory cytokines―which play an important role in pathologic processes―may contribute to inflammatory disorders. Cytokine polymorphisms are known to have an impact on gene expression. The purpose of this study was to search for the relationship between the IFNG polymorphisms and the levels of proinflammatory cytokines. Materials and Methods: This study, conducted in West Pomeranian Voivodeship, Poland, involved 416 women. Of these women, 33.6% of them had primary education, 44.8% lived in cities with a population of over 100,000, and 82.7% were married. Of the participants, 28.4% met the criteria for MetS. The study involved: interview performed to collect sociodemographic and medical data, anthropometric measurements, as well as venous blood collection for biochemical analysis, genetic testing and the measurement of inflammatory markers. Results: The link between the IFNG (rs2430561) polymorphism and serum PIC (proinflammatory cytokines) levels was tested with regard to MetS. In the MetS+ subgroup, the T/T and A/T genotypes of the IFNG gene were accompanied by higher IL-6 levels than in the MetS− subgroup. Conclusion: Our study has not confirmed a direct link between the IFNG polymorphisms and the levels of inflammatory biomarkers. Nevertheless, the T/T and A/T genotypes of the IFNG gene may predispose to elevated IL-6 levels.
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spelling pubmed-74662412020-09-14 The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women Schneider-Matyka, Daria Szkup, Małgorzata Owczarek, Aleksander Jerzy Stanisławska, Marzanna Knyszyńska, Anna Lubkowska, Anna Grochans, Elżbieta Jurczak, Anna Medicina (Kaunas) Article Background and Objectives: Metabolic syndrome (MetS) is a multiple risk factor for atherosclerosis, cardiovascular disease, type 2 diabetes and strokes. One-third of middle-age women are at risk of MetS, which predisposes them to type 2 diabetes and cardiovascular disease. Changes in the regulation of anti-inflammatory cytokines―which play an important role in pathologic processes―may contribute to inflammatory disorders. Cytokine polymorphisms are known to have an impact on gene expression. The purpose of this study was to search for the relationship between the IFNG polymorphisms and the levels of proinflammatory cytokines. Materials and Methods: This study, conducted in West Pomeranian Voivodeship, Poland, involved 416 women. Of these women, 33.6% of them had primary education, 44.8% lived in cities with a population of over 100,000, and 82.7% were married. Of the participants, 28.4% met the criteria for MetS. The study involved: interview performed to collect sociodemographic and medical data, anthropometric measurements, as well as venous blood collection for biochemical analysis, genetic testing and the measurement of inflammatory markers. Results: The link between the IFNG (rs2430561) polymorphism and serum PIC (proinflammatory cytokines) levels was tested with regard to MetS. In the MetS+ subgroup, the T/T and A/T genotypes of the IFNG gene were accompanied by higher IL-6 levels than in the MetS− subgroup. Conclusion: Our study has not confirmed a direct link between the IFNG polymorphisms and the levels of inflammatory biomarkers. Nevertheless, the T/T and A/T genotypes of the IFNG gene may predispose to elevated IL-6 levels. MDPI 2020-07-31 /pmc/articles/PMC7466241/ /pubmed/32751810 http://dx.doi.org/10.3390/medicina56080384 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schneider-Matyka, Daria
Szkup, Małgorzata
Owczarek, Aleksander Jerzy
Stanisławska, Marzanna
Knyszyńska, Anna
Lubkowska, Anna
Grochans, Elżbieta
Jurczak, Anna
The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
title The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
title_full The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
title_fullStr The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
title_full_unstemmed The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
title_short The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
title_sort relationship between the ifng (rs2430561) polymorphism and metabolic syndrome in perimenopausal women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466241/
https://www.ncbi.nlm.nih.gov/pubmed/32751810
http://dx.doi.org/10.3390/medicina56080384
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