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Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics

X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects,...

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Autores principales: Winter, Hayden, Neufeld, Megan J., Makotamo, Lydia, Sun, Conroy, Goforth, Andrea M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466269/
https://www.ncbi.nlm.nih.gov/pubmed/32722132
http://dx.doi.org/10.3390/nano10081447
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author Winter, Hayden
Neufeld, Megan J.
Makotamo, Lydia
Sun, Conroy
Goforth, Andrea M.
author_facet Winter, Hayden
Neufeld, Megan J.
Makotamo, Lydia
Sun, Conroy
Goforth, Andrea M.
author_sort Winter, Hayden
collection PubMed
description X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF(2) core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu during the CaF(2) core synthesis to prepare nanoparticles (NPs) with X-ray luminescent properties for potential application in fluorescence imaging. The mesoporous silica shell was added to provide the opportunity for small molecule loading, and the polyethylene glycol coating was added to impart aqueous solubility and biocompatibility. The potential of these nanomaterials to act as radiosensitizers for enhancing X-ray radiotherapy was supported by reactive oxygen species generation assays. Further, in vitro experiments indicate biocompatibility and enhanced cellular damage during X-ray radiotherapy.
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spelling pubmed-74662692020-09-14 Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics Winter, Hayden Neufeld, Megan J. Makotamo, Lydia Sun, Conroy Goforth, Andrea M. Nanomaterials (Basel) Article X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF(2) core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu during the CaF(2) core synthesis to prepare nanoparticles (NPs) with X-ray luminescent properties for potential application in fluorescence imaging. The mesoporous silica shell was added to provide the opportunity for small molecule loading, and the polyethylene glycol coating was added to impart aqueous solubility and biocompatibility. The potential of these nanomaterials to act as radiosensitizers for enhancing X-ray radiotherapy was supported by reactive oxygen species generation assays. Further, in vitro experiments indicate biocompatibility and enhanced cellular damage during X-ray radiotherapy. MDPI 2020-07-24 /pmc/articles/PMC7466269/ /pubmed/32722132 http://dx.doi.org/10.3390/nano10081447 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Winter, Hayden
Neufeld, Megan J.
Makotamo, Lydia
Sun, Conroy
Goforth, Andrea M.
Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
title Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
title_full Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
title_fullStr Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
title_full_unstemmed Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
title_short Synthesis of Radioluminescent CaF(2):Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
title_sort synthesis of radioluminescent caf(2):ln core, mesoporous silica shell nanoparticles for use in x-ray based theranostics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466269/
https://www.ncbi.nlm.nih.gov/pubmed/32722132
http://dx.doi.org/10.3390/nano10081447
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