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An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans

Monoterpenes are bioactive compounds, however studies on their metabolic fate in humans are scarce. The present work aimed to identify and quantify the bioactive monoterpenes myrcene, α- and β-pinene of the Mediterranean product Mastiha Oil, in human plasma after acute consumption of a single dose....

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Autores principales: Papada, Efstathia, Gioxari, Aristea, Amerikanou, Charalampia, Galanis, Nikolaos, Kaliora, Andriana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466295/
https://www.ncbi.nlm.nih.gov/pubmed/32751415
http://dx.doi.org/10.3390/foods9081019
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author Papada, Efstathia
Gioxari, Aristea
Amerikanou, Charalampia
Galanis, Nikolaos
Kaliora, Andriana C.
author_facet Papada, Efstathia
Gioxari, Aristea
Amerikanou, Charalampia
Galanis, Nikolaos
Kaliora, Andriana C.
author_sort Papada, Efstathia
collection PubMed
description Monoterpenes are bioactive compounds, however studies on their metabolic fate in humans are scarce. The present work aimed to identify and quantify the bioactive monoterpenes myrcene, α- and β-pinene of the Mediterranean product Mastiha Oil, in human plasma after acute consumption of a single dose. This was an open-label, single-arm acute study. After overnight fasting, healthy males were administered with Mastiha Oil. Blood samples were collected on different time-points before and after consumption. A novel GC-MS-MS application was performed to detect and quantify terpenes in MO and in plasma. Serum lipid resistance to oxidation was also determined. Alpha-Pinene, β-pinene and myrcene were identified and quantified in plasma. Alpha-pinene concentration significantly increased after 0.5 h of Mastiha Oil consumption, remaining significantly increased at 1 h, 2 h, 4 h, 6 h and 24 h. Beta-pinene and myrcene followed similar patterns. The increase in serum lipid resistance to oxidation was significant at 1 h, reached its peak at 2 h and remained significant until 4 h. Conclusively, α-pinene, β-pinene and myrcene that are present in Mastiha Oil are absorbed by humans. (ClinicalTrials.gov Identifier: NCT04290312).
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spelling pubmed-74662952020-09-14 An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans Papada, Efstathia Gioxari, Aristea Amerikanou, Charalampia Galanis, Nikolaos Kaliora, Andriana C. Foods Article Monoterpenes are bioactive compounds, however studies on their metabolic fate in humans are scarce. The present work aimed to identify and quantify the bioactive monoterpenes myrcene, α- and β-pinene of the Mediterranean product Mastiha Oil, in human plasma after acute consumption of a single dose. This was an open-label, single-arm acute study. After overnight fasting, healthy males were administered with Mastiha Oil. Blood samples were collected on different time-points before and after consumption. A novel GC-MS-MS application was performed to detect and quantify terpenes in MO and in plasma. Serum lipid resistance to oxidation was also determined. Alpha-Pinene, β-pinene and myrcene were identified and quantified in plasma. Alpha-pinene concentration significantly increased after 0.5 h of Mastiha Oil consumption, remaining significantly increased at 1 h, 2 h, 4 h, 6 h and 24 h. Beta-pinene and myrcene followed similar patterns. The increase in serum lipid resistance to oxidation was significant at 1 h, reached its peak at 2 h and remained significant until 4 h. Conclusively, α-pinene, β-pinene and myrcene that are present in Mastiha Oil are absorbed by humans. (ClinicalTrials.gov Identifier: NCT04290312). MDPI 2020-07-30 /pmc/articles/PMC7466295/ /pubmed/32751415 http://dx.doi.org/10.3390/foods9081019 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Papada, Efstathia
Gioxari, Aristea
Amerikanou, Charalampia
Galanis, Nikolaos
Kaliora, Andriana C.
An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans
title An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans
title_full An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans
title_fullStr An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans
title_full_unstemmed An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans
title_short An Absorption and Plasma Kinetics Study of Monoterpenes Present in Mastiha Oil in Humans
title_sort absorption and plasma kinetics study of monoterpenes present in mastiha oil in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466295/
https://www.ncbi.nlm.nih.gov/pubmed/32751415
http://dx.doi.org/10.3390/foods9081019
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