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Prognostic Markers of Myelodysplastic Syndromes

Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interp...

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Autores principales: Veryaskina, Yuliya Andreevna, Titov, Sergei Evgenievich, Kovynev, Igor Borisovich, Pospelova, Tatiana Ivanovna, Zhimulev, Igor Fyodorovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466347/
https://www.ncbi.nlm.nih.gov/pubmed/32727068
http://dx.doi.org/10.3390/medicina56080376
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author Veryaskina, Yuliya Andreevna
Titov, Sergei Evgenievich
Kovynev, Igor Borisovich
Pospelova, Tatiana Ivanovna
Zhimulev, Igor Fyodorovich
author_facet Veryaskina, Yuliya Andreevna
Titov, Sergei Evgenievich
Kovynev, Igor Borisovich
Pospelova, Tatiana Ivanovna
Zhimulev, Igor Fyodorovich
author_sort Veryaskina, Yuliya Andreevna
collection PubMed
description Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interplay between genetic and epigenetic factors, including miRNA. In practice, karyotype analysis assigns patients to different prognostic groups, and mutations are often associated with a particular disease phenotype. Among myeloproliferative disorders, secondary MDS is a group of special entities with a typical spectrum of genetic mutations and cytogenetic rearrangements resembling those in de novo MDS. This overview analyzes the present prognostic systems of MDS and the most recent efforts in the search for genetic and epigenetic markers for the diagnosis and prognosis of MDS.
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spelling pubmed-74663472020-09-14 Prognostic Markers of Myelodysplastic Syndromes Veryaskina, Yuliya Andreevna Titov, Sergei Evgenievich Kovynev, Igor Borisovich Pospelova, Tatiana Ivanovna Zhimulev, Igor Fyodorovich Medicina (Kaunas) Review Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interplay between genetic and epigenetic factors, including miRNA. In practice, karyotype analysis assigns patients to different prognostic groups, and mutations are often associated with a particular disease phenotype. Among myeloproliferative disorders, secondary MDS is a group of special entities with a typical spectrum of genetic mutations and cytogenetic rearrangements resembling those in de novo MDS. This overview analyzes the present prognostic systems of MDS and the most recent efforts in the search for genetic and epigenetic markers for the diagnosis and prognosis of MDS. MDPI 2020-07-27 /pmc/articles/PMC7466347/ /pubmed/32727068 http://dx.doi.org/10.3390/medicina56080376 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Veryaskina, Yuliya Andreevna
Titov, Sergei Evgenievich
Kovynev, Igor Borisovich
Pospelova, Tatiana Ivanovna
Zhimulev, Igor Fyodorovich
Prognostic Markers of Myelodysplastic Syndromes
title Prognostic Markers of Myelodysplastic Syndromes
title_full Prognostic Markers of Myelodysplastic Syndromes
title_fullStr Prognostic Markers of Myelodysplastic Syndromes
title_full_unstemmed Prognostic Markers of Myelodysplastic Syndromes
title_short Prognostic Markers of Myelodysplastic Syndromes
title_sort prognostic markers of myelodysplastic syndromes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466347/
https://www.ncbi.nlm.nih.gov/pubmed/32727068
http://dx.doi.org/10.3390/medicina56080376
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