Cargando…
Prognostic Markers of Myelodysplastic Syndromes
Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interp...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466347/ https://www.ncbi.nlm.nih.gov/pubmed/32727068 http://dx.doi.org/10.3390/medicina56080376 |
_version_ | 1783577792087064576 |
---|---|
author | Veryaskina, Yuliya Andreevna Titov, Sergei Evgenievich Kovynev, Igor Borisovich Pospelova, Tatiana Ivanovna Zhimulev, Igor Fyodorovich |
author_facet | Veryaskina, Yuliya Andreevna Titov, Sergei Evgenievich Kovynev, Igor Borisovich Pospelova, Tatiana Ivanovna Zhimulev, Igor Fyodorovich |
author_sort | Veryaskina, Yuliya Andreevna |
collection | PubMed |
description | Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interplay between genetic and epigenetic factors, including miRNA. In practice, karyotype analysis assigns patients to different prognostic groups, and mutations are often associated with a particular disease phenotype. Among myeloproliferative disorders, secondary MDS is a group of special entities with a typical spectrum of genetic mutations and cytogenetic rearrangements resembling those in de novo MDS. This overview analyzes the present prognostic systems of MDS and the most recent efforts in the search for genetic and epigenetic markers for the diagnosis and prognosis of MDS. |
format | Online Article Text |
id | pubmed-7466347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74663472020-09-14 Prognostic Markers of Myelodysplastic Syndromes Veryaskina, Yuliya Andreevna Titov, Sergei Evgenievich Kovynev, Igor Borisovich Pospelova, Tatiana Ivanovna Zhimulev, Igor Fyodorovich Medicina (Kaunas) Review Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interplay between genetic and epigenetic factors, including miRNA. In practice, karyotype analysis assigns patients to different prognostic groups, and mutations are often associated with a particular disease phenotype. Among myeloproliferative disorders, secondary MDS is a group of special entities with a typical spectrum of genetic mutations and cytogenetic rearrangements resembling those in de novo MDS. This overview analyzes the present prognostic systems of MDS and the most recent efforts in the search for genetic and epigenetic markers for the diagnosis and prognosis of MDS. MDPI 2020-07-27 /pmc/articles/PMC7466347/ /pubmed/32727068 http://dx.doi.org/10.3390/medicina56080376 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Veryaskina, Yuliya Andreevna Titov, Sergei Evgenievich Kovynev, Igor Borisovich Pospelova, Tatiana Ivanovna Zhimulev, Igor Fyodorovich Prognostic Markers of Myelodysplastic Syndromes |
title | Prognostic Markers of Myelodysplastic Syndromes |
title_full | Prognostic Markers of Myelodysplastic Syndromes |
title_fullStr | Prognostic Markers of Myelodysplastic Syndromes |
title_full_unstemmed | Prognostic Markers of Myelodysplastic Syndromes |
title_short | Prognostic Markers of Myelodysplastic Syndromes |
title_sort | prognostic markers of myelodysplastic syndromes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466347/ https://www.ncbi.nlm.nih.gov/pubmed/32727068 http://dx.doi.org/10.3390/medicina56080376 |
work_keys_str_mv | AT veryaskinayuliyaandreevna prognosticmarkersofmyelodysplasticsyndromes AT titovsergeievgenievich prognosticmarkersofmyelodysplasticsyndromes AT kovynevigorborisovich prognosticmarkersofmyelodysplasticsyndromes AT pospelovatatianaivanovna prognosticmarkersofmyelodysplasticsyndromes AT zhimulevigorfyodorovich prognosticmarkersofmyelodysplasticsyndromes |