Toll-Like Receptor 4 Expression on Lymphoma Cells Is Critical for Therapeutic Activity of Intratumoral Therapy With Synthetic TLR4 Agonist Glucopyranosyl Lipid A

Intratumoral (IT) injections of Glucopyranosyl lipid A (G100), a synthetic toll-like receptor 4 (TLR4) agonist formulated in a stable emulsion, resulted in T-cell inflammation of the tumor microenvironment (TME) and complete cure of 60% of mice with large established A20 lymphomas. Strong abscopal e...

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Detalles Bibliográficos
Autores principales: Lu, Hailing, Betancur, Alec, Chen, Michael, ter Meulen, Jan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466407/
https://www.ncbi.nlm.nih.gov/pubmed/32974162
http://dx.doi.org/10.3389/fonc.2020.01438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466407/
https://www.ncbi.nlm.nih.gov/pubmed/32974162
http://dx.doi.org/10.3389/fonc.2020.01438

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