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Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection
BACKGROUND: Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) cells play a crucial role in promoting antibody production. This study investig...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466526/ https://www.ncbi.nlm.nih.gov/pubmed/32873255 http://dx.doi.org/10.1186/s12865-020-00379-4 |
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author | Shen, Weiyun Ye, Hongzhou Zhang, Xilin Huo, Lixia Shen, Jingli Zhu, Li Wang, Xiang Cui, Dawei |
author_facet | Shen, Weiyun Ye, Hongzhou Zhang, Xilin Huo, Lixia Shen, Jingli Zhu, Li Wang, Xiang Cui, Dawei |
author_sort | Shen, Weiyun |
collection | PubMed |
description | BACKGROUND: Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) cells play a crucial role in promoting antibody production. This study investigated the potential role of Tfh cells in peripheral blood mononuclear cells (PBMCs) from children with acute MeV infection. RESULTS: The frequencies of CXCR5(+)CD4(+) Tfh, ICOS(high) Tfh, and PD-1(high) Tfh cells in PBMCs and levels of IL-6 and IL-21 in plasma were significantly elevated in patients with acute MeV infection. Moreover, a positive correlation was discovered among the frequency of ICOS(high) Tfh cells, plasma levels of IL-21 and optical density (OD) values of MeV-specific IgM antibodies in the patients with acute MeV infection. However, elevated plasma MeV-specific NAb titres were not associated with the frequency of Tfh, ICOS(high) Tfh, or PD-1(high) Tfh cells in the patients with acute MeV infection. CONCLUSION: These results suggest that an elevated Tfh cell frequency and associated molecules possibly play a key role in children with acute MeV infection, which contributes to the prevention and treatment of MeV infection in children. |
format | Online Article Text |
id | pubmed-7466526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74665262020-09-03 Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection Shen, Weiyun Ye, Hongzhou Zhang, Xilin Huo, Lixia Shen, Jingli Zhu, Li Wang, Xiang Cui, Dawei BMC Immunol Research Article BACKGROUND: Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) cells play a crucial role in promoting antibody production. This study investigated the potential role of Tfh cells in peripheral blood mononuclear cells (PBMCs) from children with acute MeV infection. RESULTS: The frequencies of CXCR5(+)CD4(+) Tfh, ICOS(high) Tfh, and PD-1(high) Tfh cells in PBMCs and levels of IL-6 and IL-21 in plasma were significantly elevated in patients with acute MeV infection. Moreover, a positive correlation was discovered among the frequency of ICOS(high) Tfh cells, plasma levels of IL-21 and optical density (OD) values of MeV-specific IgM antibodies in the patients with acute MeV infection. However, elevated plasma MeV-specific NAb titres were not associated with the frequency of Tfh, ICOS(high) Tfh, or PD-1(high) Tfh cells in the patients with acute MeV infection. CONCLUSION: These results suggest that an elevated Tfh cell frequency and associated molecules possibly play a key role in children with acute MeV infection, which contributes to the prevention and treatment of MeV infection in children. BioMed Central 2020-09-01 /pmc/articles/PMC7466526/ /pubmed/32873255 http://dx.doi.org/10.1186/s12865-020-00379-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Shen, Weiyun Ye, Hongzhou Zhang, Xilin Huo, Lixia Shen, Jingli Zhu, Li Wang, Xiang Cui, Dawei Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection |
title | Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection |
title_full | Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection |
title_fullStr | Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection |
title_full_unstemmed | Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection |
title_short | Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection |
title_sort | elevated expansion of follicular helper t cells in peripheral blood from children with acute measles infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466526/ https://www.ncbi.nlm.nih.gov/pubmed/32873255 http://dx.doi.org/10.1186/s12865-020-00379-4 |
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