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A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite

The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and...

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Autores principales: Palakollu, Venkata Narayana, Karpoormath, Rajshekhar, Wang, Lei, Tang, Jiao-Ning, Liu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466556/
https://www.ncbi.nlm.nih.gov/pubmed/32752281
http://dx.doi.org/10.3390/nano10081513
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author Palakollu, Venkata Narayana
Karpoormath, Rajshekhar
Wang, Lei
Tang, Jiao-Ning
Liu, Chen
author_facet Palakollu, Venkata Narayana
Karpoormath, Rajshekhar
Wang, Lei
Tang, Jiao-Ning
Liu, Chen
author_sort Palakollu, Venkata Narayana
collection PubMed
description The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and sensitive electrochemical sensor was developed for the detection of antipsychotic drug CPZ based on a Nafion (Nf)-supported nitrogen-doped carbon dots/cuprous oxide (N-CDs/Cu(2)O) composite. The as-synthesized N-CDs/Cu(2)O composite was systematically characterized using various physicochemical techniques. The developed composite-based sensor displayed excellent performance towards CPZ determination in a dynamic linear range of 0.001–230 µM with the detection limit of 25 nM. Remarkably, the developed sensor displayed good performance in terms of sensitivity and selectivity. Furthermore, good anti-interference properties toward CPZ determination were attained despite the presence of highly concentrated interfering compounds. Therefore, this composite could be a notable potential modifier to enhance electrocatalytic activity onto the surface of the electrode. Finally, N-CDs/Cu(2)O/Nf-based sensor was effectively applied for quantification of CPZ in human urine and pharmaceutical formulation samples.
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spelling pubmed-74665562020-09-14 A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite Palakollu, Venkata Narayana Karpoormath, Rajshekhar Wang, Lei Tang, Jiao-Ning Liu, Chen Nanomaterials (Basel) Article The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and sensitive electrochemical sensor was developed for the detection of antipsychotic drug CPZ based on a Nafion (Nf)-supported nitrogen-doped carbon dots/cuprous oxide (N-CDs/Cu(2)O) composite. The as-synthesized N-CDs/Cu(2)O composite was systematically characterized using various physicochemical techniques. The developed composite-based sensor displayed excellent performance towards CPZ determination in a dynamic linear range of 0.001–230 µM with the detection limit of 25 nM. Remarkably, the developed sensor displayed good performance in terms of sensitivity and selectivity. Furthermore, good anti-interference properties toward CPZ determination were attained despite the presence of highly concentrated interfering compounds. Therefore, this composite could be a notable potential modifier to enhance electrocatalytic activity onto the surface of the electrode. Finally, N-CDs/Cu(2)O/Nf-based sensor was effectively applied for quantification of CPZ in human urine and pharmaceutical formulation samples. MDPI 2020-08-01 /pmc/articles/PMC7466556/ /pubmed/32752281 http://dx.doi.org/10.3390/nano10081513 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Palakollu, Venkata Narayana
Karpoormath, Rajshekhar
Wang, Lei
Tang, Jiao-Ning
Liu, Chen
A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
title A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
title_full A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
title_fullStr A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
title_full_unstemmed A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
title_short A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
title_sort versatile and ultrasensitive electrochemical sensing platform for detection of chlorpromazine based on nitrogen-doped carbon dots/cuprous oxide composite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466556/
https://www.ncbi.nlm.nih.gov/pubmed/32752281
http://dx.doi.org/10.3390/nano10081513
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