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A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite
The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466556/ https://www.ncbi.nlm.nih.gov/pubmed/32752281 http://dx.doi.org/10.3390/nano10081513 |
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author | Palakollu, Venkata Narayana Karpoormath, Rajshekhar Wang, Lei Tang, Jiao-Ning Liu, Chen |
author_facet | Palakollu, Venkata Narayana Karpoormath, Rajshekhar Wang, Lei Tang, Jiao-Ning Liu, Chen |
author_sort | Palakollu, Venkata Narayana |
collection | PubMed |
description | The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and sensitive electrochemical sensor was developed for the detection of antipsychotic drug CPZ based on a Nafion (Nf)-supported nitrogen-doped carbon dots/cuprous oxide (N-CDs/Cu(2)O) composite. The as-synthesized N-CDs/Cu(2)O composite was systematically characterized using various physicochemical techniques. The developed composite-based sensor displayed excellent performance towards CPZ determination in a dynamic linear range of 0.001–230 µM with the detection limit of 25 nM. Remarkably, the developed sensor displayed good performance in terms of sensitivity and selectivity. Furthermore, good anti-interference properties toward CPZ determination were attained despite the presence of highly concentrated interfering compounds. Therefore, this composite could be a notable potential modifier to enhance electrocatalytic activity onto the surface of the electrode. Finally, N-CDs/Cu(2)O/Nf-based sensor was effectively applied for quantification of CPZ in human urine and pharmaceutical formulation samples. |
format | Online Article Text |
id | pubmed-7466556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74665562020-09-14 A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite Palakollu, Venkata Narayana Karpoormath, Rajshekhar Wang, Lei Tang, Jiao-Ning Liu, Chen Nanomaterials (Basel) Article The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and sensitive electrochemical sensor was developed for the detection of antipsychotic drug CPZ based on a Nafion (Nf)-supported nitrogen-doped carbon dots/cuprous oxide (N-CDs/Cu(2)O) composite. The as-synthesized N-CDs/Cu(2)O composite was systematically characterized using various physicochemical techniques. The developed composite-based sensor displayed excellent performance towards CPZ determination in a dynamic linear range of 0.001–230 µM with the detection limit of 25 nM. Remarkably, the developed sensor displayed good performance in terms of sensitivity and selectivity. Furthermore, good anti-interference properties toward CPZ determination were attained despite the presence of highly concentrated interfering compounds. Therefore, this composite could be a notable potential modifier to enhance electrocatalytic activity onto the surface of the electrode. Finally, N-CDs/Cu(2)O/Nf-based sensor was effectively applied for quantification of CPZ in human urine and pharmaceutical formulation samples. MDPI 2020-08-01 /pmc/articles/PMC7466556/ /pubmed/32752281 http://dx.doi.org/10.3390/nano10081513 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palakollu, Venkata Narayana Karpoormath, Rajshekhar Wang, Lei Tang, Jiao-Ning Liu, Chen A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite |
title | A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite |
title_full | A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite |
title_fullStr | A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite |
title_full_unstemmed | A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite |
title_short | A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite |
title_sort | versatile and ultrasensitive electrochemical sensing platform for detection of chlorpromazine based on nitrogen-doped carbon dots/cuprous oxide composite |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466556/ https://www.ncbi.nlm.nih.gov/pubmed/32752281 http://dx.doi.org/10.3390/nano10081513 |
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