Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Anqi, Yu, Hui, Liu, Jiayi, Zheng, Jianan, Jia, Yinan, Wu, Bingfeng, Xiang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466665/
https://www.ncbi.nlm.nih.gov/pubmed/32974339
http://dx.doi.org/10.3389/fcell.2020.00780
_version_ 1783577865930932224
author Zhou, Anqi
Yu, Hui
Liu, Jiayi
Zheng, Jianan
Jia, Yinan
Wu, Bingfeng
Xiang, Lin
author_facet Zhou, Anqi
Yu, Hui
Liu, Jiayi
Zheng, Jianan
Jia, Yinan
Wu, Bingfeng
Xiang, Lin
author_sort Zhou, Anqi
collection PubMed
description The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it’s increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes both in vitro and in vivo in a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation.
format Online
Article
Text
id pubmed-7466665
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74666652020-09-23 Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology Zhou, Anqi Yu, Hui Liu, Jiayi Zheng, Jianan Jia, Yinan Wu, Bingfeng Xiang, Lin Front Cell Dev Biol Cell and Developmental Biology The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it’s increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes both in vitro and in vivo in a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation. Frontiers Media S.A. 2020-08-19 /pmc/articles/PMC7466665/ /pubmed/32974339 http://dx.doi.org/10.3389/fcell.2020.00780 Text en Copyright © 2020 Zhou, Yu, Liu, Zheng, Jia, Wu and Xiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhou, Anqi
Yu, Hui
Liu, Jiayi
Zheng, Jianan
Jia, Yinan
Wu, Bingfeng
Xiang, Lin
Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology
title Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology
title_full Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology
title_fullStr Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology
title_full_unstemmed Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology
title_short Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology
title_sort role of hippo-yap signaling in osseointegration by regulating osteogenesis, angiogenesis, and osteoimmunology
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466665/
https://www.ncbi.nlm.nih.gov/pubmed/32974339
http://dx.doi.org/10.3389/fcell.2020.00780
work_keys_str_mv AT zhouanqi roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology
AT yuhui roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology
AT liujiayi roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology
AT zhengjianan roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology
AT jiayinan roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology
AT wubingfeng roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology
AT xianglin roleofhippoyapsignalinginosseointegrationbyregulatingosteogenesisangiogenesisandosteoimmunology

Ejemplares similares