The potential roles of exosomes in pancreatic cancer initiation and metastasis

Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of PaCa have been poorly characterized. Exosomes correspond to a class of extracellular nanovesicles, produced by a broad range...

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Detalles Bibliográficos
Autores principales: Sun, Wei, Ren, Ying, Lu, Zaiming, Zhao, Xiangxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466807/
https://www.ncbi.nlm.nih.gov/pubmed/32878635
http://dx.doi.org/10.1186/s12943-020-01255-w
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author Sun, Wei
Ren, Ying
Lu, Zaiming
Zhao, Xiangxuan
author_facet Sun, Wei
Ren, Ying
Lu, Zaiming
Zhao, Xiangxuan
author_sort Sun, Wei
collection PubMed
description Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of PaCa have been poorly characterized. Exosomes correspond to a class of extracellular nanovesicles, produced by a broad range of human somatic and cancerous cells. These particular nanovesicles are mainly composed by proteins, genetic substances and lipids, which mediate signal transduction and material transport. A large number of studies have indicated that exosomes may play decisive roles in the occurrence and metastatic progression of PaCa. This article summarizes the specific functions of exosomes and their underlying molecular mechanisms in mediating the initiation and metastatic capability of PaCa.
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spelling pubmed-74668072020-09-03 The potential roles of exosomes in pancreatic cancer initiation and metastasis Sun, Wei Ren, Ying Lu, Zaiming Zhao, Xiangxuan Mol Cancer Review Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of PaCa have been poorly characterized. Exosomes correspond to a class of extracellular nanovesicles, produced by a broad range of human somatic and cancerous cells. These particular nanovesicles are mainly composed by proteins, genetic substances and lipids, which mediate signal transduction and material transport. A large number of studies have indicated that exosomes may play decisive roles in the occurrence and metastatic progression of PaCa. This article summarizes the specific functions of exosomes and their underlying molecular mechanisms in mediating the initiation and metastatic capability of PaCa. BioMed Central 2020-09-02 /pmc/articles/PMC7466807/ /pubmed/32878635 http://dx.doi.org/10.1186/s12943-020-01255-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sun, Wei
Ren, Ying
Lu, Zaiming
Zhao, Xiangxuan
The potential roles of exosomes in pancreatic cancer initiation and metastasis
title The potential roles of exosomes in pancreatic cancer initiation and metastasis
title_full The potential roles of exosomes in pancreatic cancer initiation and metastasis
title_fullStr The potential roles of exosomes in pancreatic cancer initiation and metastasis
title_full_unstemmed The potential roles of exosomes in pancreatic cancer initiation and metastasis
title_short The potential roles of exosomes in pancreatic cancer initiation and metastasis
title_sort potential roles of exosomes in pancreatic cancer initiation and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466807/
https://www.ncbi.nlm.nih.gov/pubmed/32878635
http://dx.doi.org/10.1186/s12943-020-01255-w
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