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Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer
Immunotherapy using immune checkpoint inhibitors has opened a new era for cancer management. In colorectal cancer, patients with a phenotype of deficient mismatch repair or high microsatellite instability benefit from immunotherapy. However, the response of rest cases to immunotherapy alone is still...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466849/ https://www.ncbi.nlm.nih.gov/pubmed/32934878 http://dx.doi.org/10.1080/2162402X.2020.1773205 |
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author | Liang, Tingting Tong, Weihua Ma, Siyang Chang, Pengyu |
author_facet | Liang, Tingting Tong, Weihua Ma, Siyang Chang, Pengyu |
author_sort | Liang, Tingting |
collection | PubMed |
description | Immunotherapy using immune checkpoint inhibitors has opened a new era for cancer management. In colorectal cancer, patients with a phenotype of deficient mismatch repair or high microsatellite instability benefit from immunotherapy. However, the response of rest cases to immunotherapy alone is still poor. Nevertheless, preclinical data have revealed that either ionizing irradiation or chemotherapy can improve the tumoral immune milieu, because these approaches can induce immunogenic cell death among cancer cells. In this regard, combination use of standard therapy plus immunotherapy should be feasible. In this review, we will introduce the specific roles of standard therapies, including radiotherapy, chemotherapy, antiangiogenic and anti-EGFR therapy, in improving therapeutic effect of immune checkpoint inhibitors on colorectal cancer. |
format | Online Article Text |
id | pubmed-7466849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-74668492020-09-14 Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer Liang, Tingting Tong, Weihua Ma, Siyang Chang, Pengyu Oncoimmunology Review Immunotherapy using immune checkpoint inhibitors has opened a new era for cancer management. In colorectal cancer, patients with a phenotype of deficient mismatch repair or high microsatellite instability benefit from immunotherapy. However, the response of rest cases to immunotherapy alone is still poor. Nevertheless, preclinical data have revealed that either ionizing irradiation or chemotherapy can improve the tumoral immune milieu, because these approaches can induce immunogenic cell death among cancer cells. In this regard, combination use of standard therapy plus immunotherapy should be feasible. In this review, we will introduce the specific roles of standard therapies, including radiotherapy, chemotherapy, antiangiogenic and anti-EGFR therapy, in improving therapeutic effect of immune checkpoint inhibitors on colorectal cancer. Taylor & Francis 2020-06-03 /pmc/articles/PMC7466849/ /pubmed/32934878 http://dx.doi.org/10.1080/2162402X.2020.1773205 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Liang, Tingting Tong, Weihua Ma, Siyang Chang, Pengyu Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
title | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
title_full | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
title_fullStr | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
title_full_unstemmed | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
title_short | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
title_sort | standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466849/ https://www.ncbi.nlm.nih.gov/pubmed/32934878 http://dx.doi.org/10.1080/2162402X.2020.1773205 |
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