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The role of trogocytosis in immune surveillance of Hodgkin lymphoma
Hodgkin lymphoma (HL) is a unique type of hematopoietic cancer that has few tumor cells but a massive infiltration of immune cells. Findings on how the cancerous Hodgkin and Reed-Sternberg (HRS) cells survive and evade immune surveillance have facilitated the development of novel immunotherapies for...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466850/ https://www.ncbi.nlm.nih.gov/pubmed/32934884 http://dx.doi.org/10.1080/2162402X.2020.1781334 |
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author | Zeng, Qun Schwarz, Herbert |
author_facet | Zeng, Qun Schwarz, Herbert |
author_sort | Zeng, Qun |
collection | PubMed |
description | Hodgkin lymphoma (HL) is a unique type of hematopoietic cancer that has few tumor cells but a massive infiltration of immune cells. Findings on how the cancerous Hodgkin and Reed-Sternberg (HRS) cells survive and evade immune surveillance have facilitated the development of novel immunotherapies for HL. Trogocytosis is a fast process of intercellular transfer of membrane patches, which can significantly affect immune responses. In this review, we summarize the current knowledge of how trogocytosis contributes to the suppression of immune responses in HL. We focus on the ectopic expression of CD137 on HRS cells, the cause of its expression, and its implication on developing novel therapies for HL. Further, we review data demonstrating that similar mechanisms apply to CD30, PD-L1 and CTLA-4. |
format | Online Article Text |
id | pubmed-7466850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-74668502020-09-14 The role of trogocytosis in immune surveillance of Hodgkin lymphoma Zeng, Qun Schwarz, Herbert Oncoimmunology Review Hodgkin lymphoma (HL) is a unique type of hematopoietic cancer that has few tumor cells but a massive infiltration of immune cells. Findings on how the cancerous Hodgkin and Reed-Sternberg (HRS) cells survive and evade immune surveillance have facilitated the development of novel immunotherapies for HL. Trogocytosis is a fast process of intercellular transfer of membrane patches, which can significantly affect immune responses. In this review, we summarize the current knowledge of how trogocytosis contributes to the suppression of immune responses in HL. We focus on the ectopic expression of CD137 on HRS cells, the cause of its expression, and its implication on developing novel therapies for HL. Further, we review data demonstrating that similar mechanisms apply to CD30, PD-L1 and CTLA-4. Taylor & Francis 2020-06-17 /pmc/articles/PMC7466850/ /pubmed/32934884 http://dx.doi.org/10.1080/2162402X.2020.1781334 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Zeng, Qun Schwarz, Herbert The role of trogocytosis in immune surveillance of Hodgkin lymphoma |
title | The role of trogocytosis in immune surveillance of Hodgkin lymphoma |
title_full | The role of trogocytosis in immune surveillance of Hodgkin lymphoma |
title_fullStr | The role of trogocytosis in immune surveillance of Hodgkin lymphoma |
title_full_unstemmed | The role of trogocytosis in immune surveillance of Hodgkin lymphoma |
title_short | The role of trogocytosis in immune surveillance of Hodgkin lymphoma |
title_sort | role of trogocytosis in immune surveillance of hodgkin lymphoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466850/ https://www.ncbi.nlm.nih.gov/pubmed/32934884 http://dx.doi.org/10.1080/2162402X.2020.1781334 |
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