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Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors
Accumulating evidence from preclinical studies and human trials demonstrated the crucial role of the gut microbiota in determining the effectiveness of anticancer therapeutics such as immunogenic chemotherapy or immune checkpoint blockade. In summary, it appears that a diverse intestinal microbiota...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466864/ https://www.ncbi.nlm.nih.gov/pubmed/32934888 http://dx.doi.org/10.1080/2162402X.2020.1794423 |
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| author | Daillère, Romain Routy, Bertrand Goubet, Anne-Gaëlle Cogdill, Alexandria Ferrere, Gladys Alves-Costa Silva, Carolina Fluckiger, Aurélie Ly, Pierre Haddad, Yacine Pizzato, Eugenie Thelemaque, Cassandra Fidelle, Marine Mazzenga, Marine Roberti, Maria Paula Melenotte, Cléa Liu, Peng Terrisse, Safae Kepp, Oliver Kroemer, Guido Zitvogel, Laurence Derosa, Lisa |
| author_facet | Daillère, Romain Routy, Bertrand Goubet, Anne-Gaëlle Cogdill, Alexandria Ferrere, Gladys Alves-Costa Silva, Carolina Fluckiger, Aurélie Ly, Pierre Haddad, Yacine Pizzato, Eugenie Thelemaque, Cassandra Fidelle, Marine Mazzenga, Marine Roberti, Maria Paula Melenotte, Cléa Liu, Peng Terrisse, Safae Kepp, Oliver Kroemer, Guido Zitvogel, Laurence Derosa, Lisa |
| author_sort | Daillère, Romain |
| collection | PubMed |
| description | Accumulating evidence from preclinical studies and human trials demonstrated the crucial role of the gut microbiota in determining the effectiveness of anticancer therapeutics such as immunogenic chemotherapy or immune checkpoint blockade. In summary, it appears that a diverse intestinal microbiota supports therapeutic anticancer responses, while a dysbiotic microbiota composition that lacks immunostimulatory bacteria or contains overabundant immunosuppressive species causes treatment failure. In this review, we explore preclinical and translational studies highlighting how eubiotic and dysbiotic microbiota composition can affect progression-free survival in cancer patients. |
| format | Online Article Text |
| id | pubmed-7466864 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74668642020-09-14 Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors Daillère, Romain Routy, Bertrand Goubet, Anne-Gaëlle Cogdill, Alexandria Ferrere, Gladys Alves-Costa Silva, Carolina Fluckiger, Aurélie Ly, Pierre Haddad, Yacine Pizzato, Eugenie Thelemaque, Cassandra Fidelle, Marine Mazzenga, Marine Roberti, Maria Paula Melenotte, Cléa Liu, Peng Terrisse, Safae Kepp, Oliver Kroemer, Guido Zitvogel, Laurence Derosa, Lisa Oncoimmunology Review Accumulating evidence from preclinical studies and human trials demonstrated the crucial role of the gut microbiota in determining the effectiveness of anticancer therapeutics such as immunogenic chemotherapy or immune checkpoint blockade. In summary, it appears that a diverse intestinal microbiota supports therapeutic anticancer responses, while a dysbiotic microbiota composition that lacks immunostimulatory bacteria or contains overabundant immunosuppressive species causes treatment failure. In this review, we explore preclinical and translational studies highlighting how eubiotic and dysbiotic microbiota composition can affect progression-free survival in cancer patients. Taylor & Francis 2020-07-20 /pmc/articles/PMC7466864/ /pubmed/32934888 http://dx.doi.org/10.1080/2162402X.2020.1794423 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Daillère, Romain Routy, Bertrand Goubet, Anne-Gaëlle Cogdill, Alexandria Ferrere, Gladys Alves-Costa Silva, Carolina Fluckiger, Aurélie Ly, Pierre Haddad, Yacine Pizzato, Eugenie Thelemaque, Cassandra Fidelle, Marine Mazzenga, Marine Roberti, Maria Paula Melenotte, Cléa Liu, Peng Terrisse, Safae Kepp, Oliver Kroemer, Guido Zitvogel, Laurence Derosa, Lisa Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| title | Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| title_full | Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| title_fullStr | Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| title_full_unstemmed | Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| title_short | Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| title_sort | elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466864/ https://www.ncbi.nlm.nih.gov/pubmed/32934888 http://dx.doi.org/10.1080/2162402X.2020.1794423 |
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