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Update on the Clot Waveform Analysis

The activated partial thromboplastin time (APTT)–clot waveform analysis (CWA) was previously reported to be associated with the early detection of disseminated intravascular coagulation and was also reported to be able to measure very low levels of coagulation factor VIII activity. The software prog...

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Autores principales: Wada, Hideo, Matsumoto, Takeshi, Ohishi, Kohshi, Shiraki, Katsuya, Shimaoka, Motomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466886/
https://www.ncbi.nlm.nih.gov/pubmed/32862666
http://dx.doi.org/10.1177/1076029620912027
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author Wada, Hideo
Matsumoto, Takeshi
Ohishi, Kohshi
Shiraki, Katsuya
Shimaoka, Motomu
author_facet Wada, Hideo
Matsumoto, Takeshi
Ohishi, Kohshi
Shiraki, Katsuya
Shimaoka, Motomu
author_sort Wada, Hideo
collection PubMed
description The activated partial thromboplastin time (APTT)–clot waveform analysis (CWA) was previously reported to be associated with the early detection of disseminated intravascular coagulation and was also reported to be able to measure very low levels of coagulation factor VIII activity. The software program for the analysis for the APTT-CWA allows the associated first and second derivative curves (first and second DCs) to be displayed. The first and second DC reflect the velocity and acceleration, respectively. The height of the first DC reflects the “thrombin burst” and bleeding risk, while that of the second DC is useful for detecting any coagulation factor deficiency and abnormal enhancement of coagulation by phospholipids. Activated partial thromboplastin time-CWA aids in making a differential diagnosis which is difficult to do using only the routine APTT. The CWA is currently used for many applications in the clinical setting, including the monitoring of hemophilia patients and patients receiving anticoagulant therapy and the differential diagnosis of diseases.
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spelling pubmed-74668862020-09-16 Update on the Clot Waveform Analysis Wada, Hideo Matsumoto, Takeshi Ohishi, Kohshi Shiraki, Katsuya Shimaoka, Motomu Clin Appl Thromb Hemost Review The activated partial thromboplastin time (APTT)–clot waveform analysis (CWA) was previously reported to be associated with the early detection of disseminated intravascular coagulation and was also reported to be able to measure very low levels of coagulation factor VIII activity. The software program for the analysis for the APTT-CWA allows the associated first and second derivative curves (first and second DCs) to be displayed. The first and second DC reflect the velocity and acceleration, respectively. The height of the first DC reflects the “thrombin burst” and bleeding risk, while that of the second DC is useful for detecting any coagulation factor deficiency and abnormal enhancement of coagulation by phospholipids. Activated partial thromboplastin time-CWA aids in making a differential diagnosis which is difficult to do using only the routine APTT. The CWA is currently used for many applications in the clinical setting, including the monitoring of hemophilia patients and patients receiving anticoagulant therapy and the differential diagnosis of diseases. SAGE Publications 2020-08-30 /pmc/articles/PMC7466886/ /pubmed/32862666 http://dx.doi.org/10.1177/1076029620912027 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Wada, Hideo
Matsumoto, Takeshi
Ohishi, Kohshi
Shiraki, Katsuya
Shimaoka, Motomu
Update on the Clot Waveform Analysis
title Update on the Clot Waveform Analysis
title_full Update on the Clot Waveform Analysis
title_fullStr Update on the Clot Waveform Analysis
title_full_unstemmed Update on the Clot Waveform Analysis
title_short Update on the Clot Waveform Analysis
title_sort update on the clot waveform analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466886/
https://www.ncbi.nlm.nih.gov/pubmed/32862666
http://dx.doi.org/10.1177/1076029620912027
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