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Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients

BACKGROUND: The study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) patients, using (18)F-PI 2620 dynamic PET acquisition. METHODS: Thirty-four MCI patients, 6 AD patients, and 24 cognitively normal in...

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Autores principales: Chotipanich, Chanisa, Nivorn, Monchaya, Kunawudhi, Anchisa, Promteangtrong, Chetsadaporn, Boonkawin, Natphimol, Jantarato, Attapon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466905/
https://www.ncbi.nlm.nih.gov/pubmed/32862780
http://dx.doi.org/10.1177/1536012120947582
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author Chotipanich, Chanisa
Nivorn, Monchaya
Kunawudhi, Anchisa
Promteangtrong, Chetsadaporn
Boonkawin, Natphimol
Jantarato, Attapon
author_facet Chotipanich, Chanisa
Nivorn, Monchaya
Kunawudhi, Anchisa
Promteangtrong, Chetsadaporn
Boonkawin, Natphimol
Jantarato, Attapon
author_sort Chotipanich, Chanisa
collection PubMed
description BACKGROUND: The study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) patients, using (18)F-PI 2620 dynamic PET acquisition. METHODS: Thirty-four MCI patients, 6 AD patients, and 24 cognitively normal individuals were enrolled in this study. A dynamic (18)F-PI 2620 PET study was conducted at 30-75 minutes post-injection in these groups. Co-registration was applied between the dynamic acquisition PET and T1-weighted MRI to delineate various cortical regions. The standardized uptake value ratio (SUVR) was used for quantitative analysis. P-mod software with the Automated Anatomical Labeling (AAL)-merged atlas was employed to generate automatic volumes of interest for 11 brain regions. RESULTS: The curves in most brain regions presented an average SUVR stability at 30-40 minutes post-injection in each group. The appropriate uptake-timing interval of (18)F-PI 2620 was 30-75 minutes post injection for AD group and 30-40 minutes post injection for both cognitively normal individuals and MCI groups. CONCLUSION: Short uptake time around 30-40 minutes post-injection would be more comfortable and convenient for all patients, especially in those with dementia who were unable to stay motionless for long periods of scanning time in the scanner.
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spelling pubmed-74669052020-09-16 Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients Chotipanich, Chanisa Nivorn, Monchaya Kunawudhi, Anchisa Promteangtrong, Chetsadaporn Boonkawin, Natphimol Jantarato, Attapon Mol Imaging Research Article BACKGROUND: The study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) patients, using (18)F-PI 2620 dynamic PET acquisition. METHODS: Thirty-four MCI patients, 6 AD patients, and 24 cognitively normal individuals were enrolled in this study. A dynamic (18)F-PI 2620 PET study was conducted at 30-75 minutes post-injection in these groups. Co-registration was applied between the dynamic acquisition PET and T1-weighted MRI to delineate various cortical regions. The standardized uptake value ratio (SUVR) was used for quantitative analysis. P-mod software with the Automated Anatomical Labeling (AAL)-merged atlas was employed to generate automatic volumes of interest for 11 brain regions. RESULTS: The curves in most brain regions presented an average SUVR stability at 30-40 minutes post-injection in each group. The appropriate uptake-timing interval of (18)F-PI 2620 was 30-75 minutes post injection for AD group and 30-40 minutes post injection for both cognitively normal individuals and MCI groups. CONCLUSION: Short uptake time around 30-40 minutes post-injection would be more comfortable and convenient for all patients, especially in those with dementia who were unable to stay motionless for long periods of scanning time in the scanner. SAGE Publications 2020-08-31 /pmc/articles/PMC7466905/ /pubmed/32862780 http://dx.doi.org/10.1177/1536012120947582 Text en © SAGE Publications Inc. 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Chotipanich, Chanisa
Nivorn, Monchaya
Kunawudhi, Anchisa
Promteangtrong, Chetsadaporn
Boonkawin, Natphimol
Jantarato, Attapon
Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients
title Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients
title_full Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients
title_fullStr Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients
title_full_unstemmed Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients
title_short Evaluation of Imaging Windows for Tau PET Imaging Using (18)F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients
title_sort evaluation of imaging windows for tau pet imaging using (18)f-pi2620 in cognitively normal individuals, mild cognitive impairment, and alzheimer’s disease patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466905/
https://www.ncbi.nlm.nih.gov/pubmed/32862780
http://dx.doi.org/10.1177/1536012120947582
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