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Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis

BACKGROUND: we aimed to explore the relationship of acute kidney injury (AKI) with the severity and mortality of coronavirus disease 2019 (COVID-19). METHODS: A systematic literature search was conducted in PubMed, EMBASE, Scopus, Web of Science, MedRxiv Database. We compared the laboratory indicato...

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Autores principales: Ouyang, Lichen, Gong, Yeli, Zhu, Yan, Gong, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467076/
https://www.ncbi.nlm.nih.gov/pubmed/33046323
http://dx.doi.org/10.1016/j.ajem.2020.08.089
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author Ouyang, Lichen
Gong, Yeli
Zhu, Yan
Gong, Jie
author_facet Ouyang, Lichen
Gong, Yeli
Zhu, Yan
Gong, Jie
author_sort Ouyang, Lichen
collection PubMed
description BACKGROUND: we aimed to explore the relationship of acute kidney injury (AKI) with the severity and mortality of coronavirus disease 2019 (COVID-19). METHODS: A systematic literature search was conducted in PubMed, EMBASE, Scopus, Web of Science, MedRxiv Database. We compared the laboratory indicators of renal impairment and incidences of AKI in the severe versus non-severe cases, and survival versus non-survival cases, respectively. RESULTS: In 41 studies with 10,335 COVID-19 patients, the serum creatinine (sCr) in severe cases was much higher than that in non-severe cases (SMD = 0.34, 95% CI: 0.29–0.39), with a similar trend for blood urea nitrogen (BUN) (SMD = 0.66, 95%CI: 0.51–0.81), hematuria (OR = 1.59, 95% CI: 1.15–2.19), and proteinuria (OR = 2.92, 95% CI: 1.58–5.38). The estimated glomerular filtration rate decreased significantly in severe cases compared with non-severe cases (SMD = -0.45, 95% CI: −0.67– −0.23). Moreover, the pooled OR of continuous renal replacement therapy (CRRT) and AKI prevalence for severe vs. non-severe cases was 12.99 (95%CI: 4.03–41.89) and 13.16 (95%CI: 10.16–17.05), respectively. Additionally, 11 studies with 3759 COVID-19 patients were included for analysis of disease mortality. The results showed the levels of sCr and BUN in non-survival cases remarkably elevated compared with survival patients, respectively (SMD = 0.97, SMD = 1.49). The pooled OR of CRRT and AKI prevalence for non-survival vs. survival cases was 31.51 (95%CI: 6.55–151.59) and 77.48 (95%CI: 24.52–244.85), respectively. CONCLUSIONS: AKI is closely related with severity and mortality of COVID-19, which gives awareness for doctors to pay more attention for risk screening, early identification and timely treatment of AKI.
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spelling pubmed-74670762020-09-03 Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis Ouyang, Lichen Gong, Yeli Zhu, Yan Gong, Jie Am J Emerg Med Article BACKGROUND: we aimed to explore the relationship of acute kidney injury (AKI) with the severity and mortality of coronavirus disease 2019 (COVID-19). METHODS: A systematic literature search was conducted in PubMed, EMBASE, Scopus, Web of Science, MedRxiv Database. We compared the laboratory indicators of renal impairment and incidences of AKI in the severe versus non-severe cases, and survival versus non-survival cases, respectively. RESULTS: In 41 studies with 10,335 COVID-19 patients, the serum creatinine (sCr) in severe cases was much higher than that in non-severe cases (SMD = 0.34, 95% CI: 0.29–0.39), with a similar trend for blood urea nitrogen (BUN) (SMD = 0.66, 95%CI: 0.51–0.81), hematuria (OR = 1.59, 95% CI: 1.15–2.19), and proteinuria (OR = 2.92, 95% CI: 1.58–5.38). The estimated glomerular filtration rate decreased significantly in severe cases compared with non-severe cases (SMD = -0.45, 95% CI: −0.67– −0.23). Moreover, the pooled OR of continuous renal replacement therapy (CRRT) and AKI prevalence for severe vs. non-severe cases was 12.99 (95%CI: 4.03–41.89) and 13.16 (95%CI: 10.16–17.05), respectively. Additionally, 11 studies with 3759 COVID-19 patients were included for analysis of disease mortality. The results showed the levels of sCr and BUN in non-survival cases remarkably elevated compared with survival patients, respectively (SMD = 0.97, SMD = 1.49). The pooled OR of CRRT and AKI prevalence for non-survival vs. survival cases was 31.51 (95%CI: 6.55–151.59) and 77.48 (95%CI: 24.52–244.85), respectively. CONCLUSIONS: AKI is closely related with severity and mortality of COVID-19, which gives awareness for doctors to pay more attention for risk screening, early identification and timely treatment of AKI. Elsevier Inc. 2021-05 2020-09-02 /pmc/articles/PMC7467076/ /pubmed/33046323 http://dx.doi.org/10.1016/j.ajem.2020.08.089 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ouyang, Lichen
Gong, Yeli
Zhu, Yan
Gong, Jie
Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis
title Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis
title_full Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis
title_fullStr Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis
title_full_unstemmed Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis
title_short Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis
title_sort association of acute kidney injury with the severity and mortality of sars-cov-2 infection: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467076/
https://www.ncbi.nlm.nih.gov/pubmed/33046323
http://dx.doi.org/10.1016/j.ajem.2020.08.089
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