Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis

Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically active HDAC5 upregulates HBV biosynthesis. HDAC5 expression increased both the stabili...

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Autores principales: Taha, Taha Y., Anirudhan, Varada, Limothai, Umaporn, Loeb, Daniel D., Petukhov, Pavel A., McLachlan, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467325/
https://www.ncbi.nlm.nih.gov/pubmed/32822428
http://dx.doi.org/10.1371/journal.ppat.1008802
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author Taha, Taha Y.
Anirudhan, Varada
Limothai, Umaporn
Loeb, Daniel D.
Petukhov, Pavel A.
McLachlan, Alan
author_facet Taha, Taha Y.
Anirudhan, Varada
Limothai, Umaporn
Loeb, Daniel D.
Petukhov, Pavel A.
McLachlan, Alan
author_sort Taha, Taha Y.
collection PubMed
description Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically active HDAC5 upregulates HBV biosynthesis. HDAC5 expression increased both the stability and splicing of the HBV 3.5 kb RNA without altering the translational efficiency of the viral pregenomic or spliced 2.2 kb RNAs. Together, these observations point to a broader role of HDAC5 in regulating RNA splicing and transcript stability while specifically identifying a potentially novel approach toward antiviral HBV therapeutic development.
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spelling pubmed-74673252020-09-11 Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis Taha, Taha Y. Anirudhan, Varada Limothai, Umaporn Loeb, Daniel D. Petukhov, Pavel A. McLachlan, Alan PLoS Pathog Research Article Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically active HDAC5 upregulates HBV biosynthesis. HDAC5 expression increased both the stability and splicing of the HBV 3.5 kb RNA without altering the translational efficiency of the viral pregenomic or spliced 2.2 kb RNAs. Together, these observations point to a broader role of HDAC5 in regulating RNA splicing and transcript stability while specifically identifying a potentially novel approach toward antiviral HBV therapeutic development. Public Library of Science 2020-08-21 /pmc/articles/PMC7467325/ /pubmed/32822428 http://dx.doi.org/10.1371/journal.ppat.1008802 Text en © 2020 Taha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Taha, Taha Y.
Anirudhan, Varada
Limothai, Umaporn
Loeb, Daniel D.
Petukhov, Pavel A.
McLachlan, Alan
Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
title Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
title_full Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
title_fullStr Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
title_full_unstemmed Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
title_short Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
title_sort modulation of hepatitis b virus pregenomic rna stability and splicing by histone deacetylase 5 enhances viral biosynthesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467325/
https://www.ncbi.nlm.nih.gov/pubmed/32822428
http://dx.doi.org/10.1371/journal.ppat.1008802
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