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Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis

Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically active HDAC5 upregulates HBV biosynthesis. HDAC5 expression increased both the stabili...

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Detalles Bibliográficos
Autores principales:	Taha, Taha Y., Anirudhan, Varada, Limothai, Umaporn, Loeb, Daniel D., Petukhov, Pavel A., McLachlan, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467325/ https://www.ncbi.nlm.nih.gov/pubmed/32822428 http://dx.doi.org/10.1371/journal.ppat.1008802

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