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The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression

The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase, facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining genomic stability. Many APC substrates have been observed overexpressed in multiple cancer types, such as CDC20, the Aurora A and B kina...

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Detalles Bibliográficos
Autores principales:	VanGenderen, Cordell, Harkness, Troy Anthony Alan, Arnason, Terra Gayle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358/ https://www.ncbi.nlm.nih.gov/pubmed/32805721 http://dx.doi.org/10.18632/aging.103792

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