Cargando…
The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population
Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is elevated in early Alzheimer's disease (AD) and mild cognitive impairment, and is considered a biomarker for the early diagnosis of AD. However, it has not yet been investigated whether urinary AD7c-NTP is elevated with increases...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467383/ https://www.ncbi.nlm.nih.gov/pubmed/32735555 http://dx.doi.org/10.18632/aging.103356 |
_version_ | 1783578001771855872 |
---|---|
author | Li, Yuxia Guan, Shaochen Jin, He Liu, Hongjun Kang, Meimei Wang, Xiaozhen Sheng, Can Sun, Yu Li, Xuanyu Fang, Xianghua Wang, Rong |
author_facet | Li, Yuxia Guan, Shaochen Jin, He Liu, Hongjun Kang, Meimei Wang, Xiaozhen Sheng, Can Sun, Yu Li, Xuanyu Fang, Xianghua Wang, Rong |
author_sort | Li, Yuxia |
collection | PubMed |
description | Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is elevated in early Alzheimer's disease (AD) and mild cognitive impairment, and is considered a biomarker for the early diagnosis of AD. However, it has not yet been investigated whether urinary AD7c-NTP is elevated with increases in blood biochemical indicators related to AD risk factors. We recruited 2180 participants, aged 35–93 years, from communities of four districts in Beijing. Blood biochemical indicators, including blood glucose, blood lipids, renal function, and high-sensitivity C-reactive protein, were measured using routine methods. Urinary AD7c-NTP was detected using an enzyme-linked immunosorbent assay AD7c-NTP kit. In the general population, there were no significant differences in urinary AD7c-NTP levels in subjects with different Mini–Mental State Examination levels or C-reactive protein values. After adjusting for age and sex, there were significant differences in urinary AD7c-NTP levels between different education levels, marital statuses, blood glucose, blood lipids, and kidney function. There was a negative correlation between urinary AD7c-NTP levels and serum creatinine (r = –0.128). There was a positive correlation between urinary AD7c-NTP levels and HbA1c (r = 0.104), insulin (r = 0.101), and triglycerides (r = 0.093). Urinary AD7c-NTP might be useful as a potential indicator to predict AD risk. |
format | Online Article Text |
id | pubmed-7467383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-74673832020-09-14 The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population Li, Yuxia Guan, Shaochen Jin, He Liu, Hongjun Kang, Meimei Wang, Xiaozhen Sheng, Can Sun, Yu Li, Xuanyu Fang, Xianghua Wang, Rong Aging (Albany NY) Research Paper Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is elevated in early Alzheimer's disease (AD) and mild cognitive impairment, and is considered a biomarker for the early diagnosis of AD. However, it has not yet been investigated whether urinary AD7c-NTP is elevated with increases in blood biochemical indicators related to AD risk factors. We recruited 2180 participants, aged 35–93 years, from communities of four districts in Beijing. Blood biochemical indicators, including blood glucose, blood lipids, renal function, and high-sensitivity C-reactive protein, were measured using routine methods. Urinary AD7c-NTP was detected using an enzyme-linked immunosorbent assay AD7c-NTP kit. In the general population, there were no significant differences in urinary AD7c-NTP levels in subjects with different Mini–Mental State Examination levels or C-reactive protein values. After adjusting for age and sex, there were significant differences in urinary AD7c-NTP levels between different education levels, marital statuses, blood glucose, blood lipids, and kidney function. There was a negative correlation between urinary AD7c-NTP levels and serum creatinine (r = –0.128). There was a positive correlation between urinary AD7c-NTP levels and HbA1c (r = 0.104), insulin (r = 0.101), and triglycerides (r = 0.093). Urinary AD7c-NTP might be useful as a potential indicator to predict AD risk. Impact Journals 2020-07-31 /pmc/articles/PMC7467383/ /pubmed/32735555 http://dx.doi.org/10.18632/aging.103356 Text en Copyright © 2020 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Li, Yuxia Guan, Shaochen Jin, He Liu, Hongjun Kang, Meimei Wang, Xiaozhen Sheng, Can Sun, Yu Li, Xuanyu Fang, Xianghua Wang, Rong The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
title | The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
title_full | The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
title_fullStr | The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
title_full_unstemmed | The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
title_short | The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
title_sort | relationship between urinary alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467383/ https://www.ncbi.nlm.nih.gov/pubmed/32735555 http://dx.doi.org/10.18632/aging.103356 |
work_keys_str_mv | AT liyuxia therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT guanshaochen therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT jinhe therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT liuhongjun therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT kangmeimei therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT wangxiaozhen therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT shengcan therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT sunyu therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT lixuanyu therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT fangxianghua therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT wangrong therelationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT liyuxia relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT guanshaochen relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT jinhe relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT liuhongjun relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT kangmeimei relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT wangxiaozhen relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT shengcan relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT sunyu relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT lixuanyu relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT fangxianghua relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation AT wangrong relationshipbetweenurinaryalzheimerassociatedneuronalthreadproteinandbloodbiochemicalindicatorsinthegeneralpopulation |