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Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time

Leukocyte telomere length (LTL) and whole blood mitochondrial DNA (WB mtDNA) content are aging markers impacted by chronic diseases such as human immunodeficiency virus (HIV) infection. We characterized the relationship between these two markers in 312 women ≥12 years of age living with HIV and 300...

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Autores principales: Hsieh, Anthony Y.Y., Kimmel, Elana, Pick, Neora, Sauvé, Laura, Brophy, Jason, Kakkar, Fatima, Bitnun, Ari, Murray, Melanie C.M., Côté, Hélène C.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467389/
https://www.ncbi.nlm.nih.gov/pubmed/32703912
http://dx.doi.org/10.18632/aging.103703
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author Hsieh, Anthony Y.Y.
Kimmel, Elana
Pick, Neora
Sauvé, Laura
Brophy, Jason
Kakkar, Fatima
Bitnun, Ari
Murray, Melanie C.M.
Côté, Hélène C.F.
author_facet Hsieh, Anthony Y.Y.
Kimmel, Elana
Pick, Neora
Sauvé, Laura
Brophy, Jason
Kakkar, Fatima
Bitnun, Ari
Murray, Melanie C.M.
Côté, Hélène C.F.
author_sort Hsieh, Anthony Y.Y.
collection PubMed
description Leukocyte telomere length (LTL) and whole blood mitochondrial DNA (WB mtDNA) content are aging markers impacted by chronic diseases such as human immunodeficiency virus (HIV) infection. We characterized the relationship between these two markers in 312 women ≥12 years of age living with HIV and 300 HIV-negative controls. We found no relationship between the two markers cross-sectionally. In multivariable models, age, ethnicity, HIV, and tobacco smoking were independently associated with shorter LTL, and the former three with lower WB mtDNA. Longitudinally, among a subgroup of 228 HIV participants and 68 HIV-negative controls with ≥2 biospecimens ≥1 year apart, an inverted pattern was observed between the rates of change in LTL and WB mtDNA content per year, whereby faster decline of one was associated with the preservation of the other. Furthermore, if HIV viral control was not maintained between visits, increased rates of both LTL attrition and WB mtDNA loss were observed. We describe a novel relationship between two established aging markers, whereby rates of change in LTL and WB mtDNA are inversely related. Our findings highlight the importance of maintaining HIV viral control, the complementary longitudinal relationship between the two markers, and the need to consider both in aging studies.
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spelling pubmed-74673892020-09-14 Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time Hsieh, Anthony Y.Y. Kimmel, Elana Pick, Neora Sauvé, Laura Brophy, Jason Kakkar, Fatima Bitnun, Ari Murray, Melanie C.M. Côté, Hélène C.F. Aging (Albany NY) Research Paper Leukocyte telomere length (LTL) and whole blood mitochondrial DNA (WB mtDNA) content are aging markers impacted by chronic diseases such as human immunodeficiency virus (HIV) infection. We characterized the relationship between these two markers in 312 women ≥12 years of age living with HIV and 300 HIV-negative controls. We found no relationship between the two markers cross-sectionally. In multivariable models, age, ethnicity, HIV, and tobacco smoking were independently associated with shorter LTL, and the former three with lower WB mtDNA. Longitudinally, among a subgroup of 228 HIV participants and 68 HIV-negative controls with ≥2 biospecimens ≥1 year apart, an inverted pattern was observed between the rates of change in LTL and WB mtDNA content per year, whereby faster decline of one was associated with the preservation of the other. Furthermore, if HIV viral control was not maintained between visits, increased rates of both LTL attrition and WB mtDNA loss were observed. We describe a novel relationship between two established aging markers, whereby rates of change in LTL and WB mtDNA are inversely related. Our findings highlight the importance of maintaining HIV viral control, the complementary longitudinal relationship between the two markers, and the need to consider both in aging studies. Impact Journals 2020-07-23 /pmc/articles/PMC7467389/ /pubmed/32703912 http://dx.doi.org/10.18632/aging.103703 Text en Copyright © 2020 Hsieh et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Hsieh, Anthony Y.Y.
Kimmel, Elana
Pick, Neora
Sauvé, Laura
Brophy, Jason
Kakkar, Fatima
Bitnun, Ari
Murray, Melanie C.M.
Côté, Hélène C.F.
Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time
title Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time
title_full Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time
title_fullStr Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time
title_full_unstemmed Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time
title_short Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time
title_sort inverse relationship between leukocyte telomere length attrition and blood mitochondrial dna content loss over time
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467389/
https://www.ncbi.nlm.nih.gov/pubmed/32703912
http://dx.doi.org/10.18632/aging.103703
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