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Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol

INTRODUCTION: Diabetes mellitus is common and growing in prevalence, and an increasing proportion of people with diabetes are living to older age. Frailty is, therefore, becoming an important concept in diabetes. Frailty is associated with older age and describes a state of increased susceptibility...

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Autores principales: Hanlon, Peter, Fauré, Isabella, Corcoran, Neave, Butterly, Elaine, Lewsey, Jim, McAllister, David A, Mair, Frances S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467518/
https://www.ncbi.nlm.nih.gov/pubmed/32873673
http://dx.doi.org/10.1136/bmjopen-2020-037476
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author Hanlon, Peter
Fauré, Isabella
Corcoran, Neave
Butterly, Elaine
Lewsey, Jim
McAllister, David A
Mair, Frances S
author_facet Hanlon, Peter
Fauré, Isabella
Corcoran, Neave
Butterly, Elaine
Lewsey, Jim
McAllister, David A
Mair, Frances S
author_sort Hanlon, Peter
collection PubMed
description INTRODUCTION: Diabetes mellitus is common and growing in prevalence, and an increasing proportion of people with diabetes are living to older age. Frailty is, therefore, becoming an important concept in diabetes. Frailty is associated with older age and describes a state of increased susceptibility to decompensation in response to physiological stress. A range of measures have been used to quantify frailty. This systematic review aims to identify measures used to quantify frailty in people with diabetes (any type); to summarise the prevalence of frailty in diabetes; and to describe the relationship between frailty and adverse clinical outcomes in people with diabetes. METHODS AND ANALYSIS: Three electronic databases (Medline, Embase and Web of Science) will be searched from 2000 to November 2019 and supplemented by citation searching of relevant articles and hand searching of reference lists. Two reviewers will independently review titles, abstracts and full texts. Inclusion criteria include: (1) adults with any type of diabetes mellitus; (2) quantify frailty using any validated frailty measure; (3) report the prevalence of frailty and/or the association between frailty and clinical outcomes in people with diabetes; (4) studies that assess generic (eg, mortality, hospital admission and falls) or diabetes-specific outcomes (eg, hypoglycaemic episodes, cardiovascular events, diabetic nephropathy and diabetic retinopathy); (5) cross-sectional and longitudinal observational studies. Study quality will be assessed using the Newcastle–Ottawa Scale for observational studies. Clinical and methodological heterogeneity will be assessed, and a random effects meta-analysis performed if appropriate. Otherwise, a narrative synthesis will be performed. ETHICS AND DISSEMINATION: This manuscript describes the protocol for a systematic review of observational studies and does not require ethical approval. PROSPERO REGISTRATION NUMBER: CRD42020163109.
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spelling pubmed-74675182020-09-11 Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol Hanlon, Peter Fauré, Isabella Corcoran, Neave Butterly, Elaine Lewsey, Jim McAllister, David A Mair, Frances S BMJ Open Diabetes and Endocrinology INTRODUCTION: Diabetes mellitus is common and growing in prevalence, and an increasing proportion of people with diabetes are living to older age. Frailty is, therefore, becoming an important concept in diabetes. Frailty is associated with older age and describes a state of increased susceptibility to decompensation in response to physiological stress. A range of measures have been used to quantify frailty. This systematic review aims to identify measures used to quantify frailty in people with diabetes (any type); to summarise the prevalence of frailty in diabetes; and to describe the relationship between frailty and adverse clinical outcomes in people with diabetes. METHODS AND ANALYSIS: Three electronic databases (Medline, Embase and Web of Science) will be searched from 2000 to November 2019 and supplemented by citation searching of relevant articles and hand searching of reference lists. Two reviewers will independently review titles, abstracts and full texts. Inclusion criteria include: (1) adults with any type of diabetes mellitus; (2) quantify frailty using any validated frailty measure; (3) report the prevalence of frailty and/or the association between frailty and clinical outcomes in people with diabetes; (4) studies that assess generic (eg, mortality, hospital admission and falls) or diabetes-specific outcomes (eg, hypoglycaemic episodes, cardiovascular events, diabetic nephropathy and diabetic retinopathy); (5) cross-sectional and longitudinal observational studies. Study quality will be assessed using the Newcastle–Ottawa Scale for observational studies. Clinical and methodological heterogeneity will be assessed, and a random effects meta-analysis performed if appropriate. Otherwise, a narrative synthesis will be performed. ETHICS AND DISSEMINATION: This manuscript describes the protocol for a systematic review of observational studies and does not require ethical approval. PROSPERO REGISTRATION NUMBER: CRD42020163109. BMJ Publishing Group 2020-09-01 /pmc/articles/PMC7467518/ /pubmed/32873673 http://dx.doi.org/10.1136/bmjopen-2020-037476 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Diabetes and Endocrinology
Hanlon, Peter
Fauré, Isabella
Corcoran, Neave
Butterly, Elaine
Lewsey, Jim
McAllister, David A
Mair, Frances S
Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
title Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
title_full Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
title_fullStr Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
title_full_unstemmed Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
title_short Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
title_sort identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
topic Diabetes and Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467518/
https://www.ncbi.nlm.nih.gov/pubmed/32873673
http://dx.doi.org/10.1136/bmjopen-2020-037476
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