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GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer
The high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmentin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467696/ https://www.ncbi.nlm.nih.gov/pubmed/32917602 http://dx.doi.org/10.1126/sciadv.abc4373 |
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author | Zhou, Zhanwei Wu, Hui Yang, Ruoxi Xu, Alan Zhang, Qingyan Dong, Jingwen Qian, Chenggen Sun, Minjie |
author_facet | Zhou, Zhanwei Wu, Hui Yang, Ruoxi Xu, Alan Zhang, Qingyan Dong, Jingwen Qian, Chenggen Sun, Minjie |
author_sort | Zhou, Zhanwei |
collection | PubMed |
description | The high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting the photothermal immunotherapy of breast cancer. The ML effectively depletes the intracellular GSH and up-regulates reactive oxygen species (ROS) in both tumor cells and DCs. In tumor cells, the ROS boosted the ABTS·(+) production to activate photothermal-induced ICD. In DCs, it relieved the immunosuppression, promoting DC maturation (57%) and antigen presenting. As a result of the ML assistant, the therapeutic systems improved the infiltration of CD8(+) T cells to 53% in tumor tissues, eliciting strong abscopal effect and antimetastasis effect. The MLs were believed to be a superior candidate of adjuvants for enhancing immune response and cancer therapeutic efficacy. |
format | Online Article Text |
id | pubmed-7467696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74676962020-09-17 GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer Zhou, Zhanwei Wu, Hui Yang, Ruoxi Xu, Alan Zhang, Qingyan Dong, Jingwen Qian, Chenggen Sun, Minjie Sci Adv Research Articles The high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting the photothermal immunotherapy of breast cancer. The ML effectively depletes the intracellular GSH and up-regulates reactive oxygen species (ROS) in both tumor cells and DCs. In tumor cells, the ROS boosted the ABTS·(+) production to activate photothermal-induced ICD. In DCs, it relieved the immunosuppression, promoting DC maturation (57%) and antigen presenting. As a result of the ML assistant, the therapeutic systems improved the infiltration of CD8(+) T cells to 53% in tumor tissues, eliciting strong abscopal effect and antimetastasis effect. The MLs were believed to be a superior candidate of adjuvants for enhancing immune response and cancer therapeutic efficacy. American Association for the Advancement of Science 2020-09-02 /pmc/articles/PMC7467696/ /pubmed/32917602 http://dx.doi.org/10.1126/sciadv.abc4373 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Zhou, Zhanwei Wu, Hui Yang, Ruoxi Xu, Alan Zhang, Qingyan Dong, Jingwen Qian, Chenggen Sun, Minjie GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
title | GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
title_full | GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
title_fullStr | GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
title_full_unstemmed | GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
title_short | GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
title_sort | gsh depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467696/ https://www.ncbi.nlm.nih.gov/pubmed/32917602 http://dx.doi.org/10.1126/sciadv.abc4373 |
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