Targeted and redox-responsive drug delivery systems based on carbonic anhydrase IX-decorated mesoporous silica nanoparticles for cancer therapy

In this work, we developed a new antibody-targeted and redox-responsive drug delivery system “MSNs-CAIX” by binding the anti-carbonic anhydrase IX antibody (A-CAIX Ab) on the surface of mesoporous silica nanoparticles (MSNs) via disulfide linkages. The design of the composite particles “MSNs-CAIX” i...

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Detalles Bibliográficos
Autores principales: Chen, Minmin, Hu, Jinxia, Wang, Lujing, Li, Yanru, Zhu, Chenghao, Chen, Chen, Shi, Ming, Ju, Zhicheng, Cao, Xichuan, Zhang, Zhuoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467921/
https://www.ncbi.nlm.nih.gov/pubmed/32879359
http://dx.doi.org/10.1038/s41598-020-71071-1

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