Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs

The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) within the bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularly injected with a single dose of MBFX (2 mg/kg). Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained for ea...

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Autores principales: IJIRI, Moe, ISHIKAWA, Shingo, JIBIKI, Yoshinori, MIYAZAWA, Masataka, SENOKUCHI, Akane, HOBO, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468076/
https://www.ncbi.nlm.nih.gov/pubmed/32565495
http://dx.doi.org/10.1292/jvms.20-0239
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author IJIRI, Moe
ISHIKAWA, Shingo
JIBIKI, Yoshinori
MIYAZAWA, Masataka
SENOKUCHI, Akane
HOBO, Seiji
author_facet IJIRI, Moe
ISHIKAWA, Shingo
JIBIKI, Yoshinori
MIYAZAWA, Masataka
SENOKUCHI, Akane
HOBO, Seiji
author_sort IJIRI, Moe
collection PubMed
description The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) within the bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularly injected with a single dose of MBFX (2 mg/kg). Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained for each pig at 0 (before administration), 3, 8 and 24 hr after administration of MBFX. As a result, the MBFX concentrations in pulmonary epithelial lining fluid (ELF) and in alveolar cells showed a similar pattern of concentrations during the experimental period. The MBFX concentrations both in ELF and alveolar cells were higher than in plasma. These results suggest that intramuscularly injected MBFX was well distributed in the bronchoalveolar region.
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spelling pubmed-74680762020-09-08 Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs IJIRI, Moe ISHIKAWA, Shingo JIBIKI, Yoshinori MIYAZAWA, Masataka SENOKUCHI, Akane HOBO, Seiji J Vet Med Sci Internal Medicine The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) within the bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularly injected with a single dose of MBFX (2 mg/kg). Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained for each pig at 0 (before administration), 3, 8 and 24 hr after administration of MBFX. As a result, the MBFX concentrations in pulmonary epithelial lining fluid (ELF) and in alveolar cells showed a similar pattern of concentrations during the experimental period. The MBFX concentrations both in ELF and alveolar cells were higher than in plasma. These results suggest that intramuscularly injected MBFX was well distributed in the bronchoalveolar region. The Japanese Society of Veterinary Science 2020-06-19 2020-08 /pmc/articles/PMC7468076/ /pubmed/32565495 http://dx.doi.org/10.1292/jvms.20-0239 Text en ©2020 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
IJIRI, Moe
ISHIKAWA, Shingo
JIBIKI, Yoshinori
MIYAZAWA, Masataka
SENOKUCHI, Akane
HOBO, Seiji
Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
title Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
title_full Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
title_fullStr Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
title_full_unstemmed Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
title_short Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
title_sort distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468076/
https://www.ncbi.nlm.nih.gov/pubmed/32565495
http://dx.doi.org/10.1292/jvms.20-0239
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