Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities

PURPOSE OF REVIEW: In 2016, the World Health Organization declared the Zika virus (ZIKV) outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. Our aim is to review the clinical and neuroimaging findings seen i...

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Autores principales: VHP, Leão, Aragão, MM, Pinho, RS, Hazin, AN, Paciorkowski, AR, Penalva de Oliveira, AC, Masruha, Marcelo Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Pediatric Neurology (WE Kaufman, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468090/
https://www.ncbi.nlm.nih.gov/pubmed/32880775
http://dx.doi.org/10.1007/s11910-020-01072-0
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author VHP, Leão
Aragão, MM
Pinho, RS
Hazin, AN
Paciorkowski, AR
Penalva de Oliveira, AC
Masruha, Marcelo Rodrigues
author_facet VHP, Leão
Aragão, MM
Pinho, RS
Hazin, AN
Paciorkowski, AR
Penalva de Oliveira, AC
Masruha, Marcelo Rodrigues
author_sort VHP, Leão
collection PubMed
description PURPOSE OF REVIEW: In 2016, the World Health Organization declared the Zika virus (ZIKV) outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. Our aim is to review the clinical and neuroimaging findings seen in congenital Zika syndrome. RECENT FINDINGS: ZIKV injures neural progenitor cells in the hippocampus, a brain region important for learning, memory, cognition, and emotion/stress response. Positron emission tomography has revealed global neuroinflammation in ZIKV infection in animal models. SUMMARY: Congenital Zika syndrome is associated with a spectrum of brain abnormalities, including microcephaly, parenchymal calcifications, malformations of cortical development and defective neuronal migration, corpus callosum abnormalities, ventriculomegaly, and brainstem and cerebellar abnormalities.
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spelling pubmed-74680902020-09-03 Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities VHP, Leão Aragão, MM Pinho, RS Hazin, AN Paciorkowski, AR Penalva de Oliveira, AC Masruha, Marcelo Rodrigues Curr Neurol Neurosci Rep Pediatric Neurology (WE Kaufman, Section Editor) PURPOSE OF REVIEW: In 2016, the World Health Organization declared the Zika virus (ZIKV) outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. Our aim is to review the clinical and neuroimaging findings seen in congenital Zika syndrome. RECENT FINDINGS: ZIKV injures neural progenitor cells in the hippocampus, a brain region important for learning, memory, cognition, and emotion/stress response. Positron emission tomography has revealed global neuroinflammation in ZIKV infection in animal models. SUMMARY: Congenital Zika syndrome is associated with a spectrum of brain abnormalities, including microcephaly, parenchymal calcifications, malformations of cortical development and defective neuronal migration, corpus callosum abnormalities, ventriculomegaly, and brainstem and cerebellar abnormalities. Springer US 2020-09-03 2020 /pmc/articles/PMC7468090/ /pubmed/32880775 http://dx.doi.org/10.1007/s11910-020-01072-0 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Pediatric Neurology (WE Kaufman, Section Editor)
VHP, Leão
Aragão, MM
Pinho, RS
Hazin, AN
Paciorkowski, AR
Penalva de Oliveira, AC
Masruha, Marcelo Rodrigues
Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
title Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
title_full Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
title_fullStr Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
title_full_unstemmed Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
title_short Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
title_sort congenital zika virus infection: a review with emphasis on the spectrum of brain abnormalities
topic Pediatric Neurology (WE Kaufman, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468090/
https://www.ncbi.nlm.nih.gov/pubmed/32880775
http://dx.doi.org/10.1007/s11910-020-01072-0
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