Modified vaccinia Ankara vaccine expressing Marburg virus-like particles protects guinea pigs from lethal Marburg virus infection

We introduce a new vaccine platform against Marburg virus (MARV) combining the advantages of the immunogenicity of a highly attenuated vaccine vector (Modified Vaccinia Ankara, MVA) with the authentic conformation of virus-like particles (VLPs). Our vaccine, MVA–MARV–VLP, expresses the minimal compo...

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Detalles Bibliográficos
Autores principales: Malherbe, Delphine C., Domi, Arban, Hauser, Mary J., Meyer, Michelle, Gunn, Bronwyn M., Alter, Galit, Bukreyev, Alexander, Guirakhoo, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468113/
https://www.ncbi.nlm.nih.gov/pubmed/32922962
http://dx.doi.org/10.1038/s41541-020-00226-y

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