Large-scale pan-cancer analysis reveals broad prognostic association between TGF-β ligands, not Hedgehog, and GLI1/2 expression in tumors

GLI1 expression is broadly accepted as a marker of Hedgehog pathway activation in tumors. Efficacy of Hedgehog inhibitors is essentially limited to tumors bearing activating mutations of the pathway. GLI2, a critical Hedgehog effector, is necessary for GLI1 expression and is a direct transcriptional...

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Detalles Bibliográficos
Autores principales: de Reyniès, Aurélien, Javelaud, Delphine, Elarouci, Nabila, Marsaud, Véronique, Gilbert, Cristèle, Mauviel, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468122/
https://www.ncbi.nlm.nih.gov/pubmed/32879407
http://dx.doi.org/10.1038/s41598-020-71559-w

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